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This study will be conducted to evaluate the effect of intravenous aminophylline on hemodynamics and recovery of patients receiving dexmedetomidine infusion during functional endoscopic sinus surgery.
Aminophylline is a nonselective adenosine receptor antagonist used for the treatment of asthma and chronic obstructive pulmonary disease. It has been used to antagonize the effects of anaesthetic and analgesic agents
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aminophylline group | Experimental | Patients will receive 4 mg/kg aminophylline diluted in 50 ml normal saline over 30 minutes. |
|
| Control group | Placebo Comparator | Patients will receive 50 ml normal saline over 30 minutes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aminophylline group | Drug | Patients will receive 4 mg/kg aminophylline diluted in 50 ml normal saline over 30 minutes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to extubation | Extubation time, defined as the interval between the discontinuation of anesthetics to safe tracheal extubation. | Two hours after discontinuation of anesthetics |
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative heart rate | Heart rate will be recorded preoperatively (baseline), after loading dose of dexmedetomidine, after intubation, every 5 minutes during the study drug infusion, then every 15 minutes until end of surgery. | Intraoperative period |
| Intraoperative mean arterial blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta University Hospitals | Tanta | ElGharbiaa | 31528 | Egypt |
The data will be available upon reasonable request from the corresponding after 6 mon from publication
after 6 mon from publication
The data will be available upon reasonable request from the corresponding
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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| normal saline | Drug | Patients will receive 50 ml normal saline over 30 minutes. |
|
Mean arterial blood pressure will be recorded preoperatively (baseline), after loading dose of dexmedetomidine, after intubation, every 5 minutes during the study drug infusion, then every 15 minutes until end of surgery. |
| Intraoperative period |
| Postoperative sedation score | Postoperative sedation will be evaluated using the Ramsay sedation score as: 1 = anxious, agitated, or restless 2= cooperative, oriented, and tranquil 3= responsive to commands 4= a sleep, but with brisk response to light, glabella tap, or loud auditory stimulus 5= a sleep, sluggish response to glabella tap, or auditory stimulus 6= a sleep, no response 6 is the highest sedation level Sedation score: will be measured at 15, 30, and 60 minutes after tracheal extubation. | 60 minutes after tracheal extubation |
| Time to discharge from post anesthesia care unit | Time needed to achieve modified Aldrete Score ≥9 will be recorded. | Two hours after tracheal extubation. |