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| Name | Class |
|---|---|
| Oriental Hepatobiliary Surgery Hospital Affiliated to Naval Military Medical University | UNKNOWN |
| Zhejiang University | OTHER |
| The First Affiliated Hospital of Nanchang University | OTHER |
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The goal of this observational study is to test in patients with cystic tumor of pancreas. The main questions it aims to answer are:
Screening of molecular diagnostic markers for pancreatic cystic tumors by cfDNA methylation sequencing of pancreatic cystic fluid and proteomic assays to distinguish benign from malignant and mucinous/non-mucinous, correlate with pathological features, and find molecular features associated with the degree of malignancy.
Participants will Provide post-operative cyst fluid specimens.
Patients with pancreatic cystic tumors were divided into control, mucinous tumor and non-mucinous tumor groups, and cfDNA molecules and protein molecules that were significantly altered between different groups were found by cfDNA methylation sequencing of pancreatic cystic fluid and proteomic detection techniques. Multi-omics analysis was performed to construct a more efficient molecular diagnostic marker model. Correlating models with pathological features to find molecular features associated with the degree of malignancy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mucinous tumour group |
| ||
| Non-mucinous tumour group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cfDNA methylation sequencing and proteome analysis | Diagnostic Test | Sequencing of cfDNA methylation and proteomic analysis of two sets of capsular fluid samples |
|
| Measure | Description | Time Frame |
|---|---|---|
| Types and concentrations of cfDNA and proteins contained in the vesicular fluid | Identification of protein and circulating gene methylation species in cyst fluid and quantification of their concentrations using mass spectrometry. Characterize cfDNA methylation and proteomics of cyst fluid in patients with pancreatic cystic neoplasm (PCN). | 2023-11-31 |
| Measure | Description | Time Frame |
|---|---|---|
| Establishment of a diagnostic model for cystic tumors of the pancreas | A machine learning approach was used to further screen for characteristically methylated cfDNA and proteins in PCN patients.Establishment of a diagnostic model for pancreatic cystic tumors. | 2023-11-31 |
| Establishing a model for the identification of mucus and non-mucus |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with pancreatic cystic tumor
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kaixuan Wang | Contact | 021-31166666 | lizfish@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Shiyu Li | Changhai Hospital | Principal Investigator |
| Chengye Pan | Changhai Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Changhai Hospital | Recruiting | Shanghai | Shanghai Municipality | 200433 | China |
cfDNA methylation data and proteome analysis data
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| ID | Term |
|---|---|
| D010190 | Pancreatic Neoplasms |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
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| West China Hospital | OTHER |
| LanZhou University | OTHER |
| First Affiliated Hospital Xi'an Jiaotong University | OTHER |
| Peking University Cancer Hospital & Institute | OTHER |
| First Hospital of China Medical University | OTHER |
| First Affiliated Hospital of Guangxi Medical University | OTHER |
| The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | OTHER |
| The Second Affiliated Hospital of Baotou Medical College | OTHER |
| Shandong Province Third hospital | OTHER |
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Cystic fluid in pancreatic cystic tumour
A machine learning approach was used to further screen for characteristically methylated cfDNA and proteins in PCN patients.To establish a model for the identification of mucinous and non-mucinous. |
| 2023-11-31 |
| Development of a progressive benign malignancy prediction model | A machine learning approach was used to further screen for characteristically methylated cfDNA and proteins in PCN patients.Development of a progression benign malignancy prediction model. | 2023-11-31 |
| D004066 |
| Digestive System Diseases |
| D010182 | Pancreatic Diseases |
| D004700 | Endocrine System Diseases |