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Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study. Patients who were given ketamine and dexmedetomidine for sedation were included in the study. The Mini Mental Status Tests of the patients measured on the first and third days of the operation in the preoperative period were determined from the hospital records and recorded.
Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study. The cognitive functions of these patients, which were evaluated by a Mini-Mental Test in the preoperative period, on the first and third days of surgery, were recorded from routine patient follow-up forms.
Sedation scores of the patients evaluated by Intraoperative Alertness/Sedation Scale (OAA/S) Observer Evaluation were recorded. Intraoperative hemodynamic data were recorded. The interventions applied to the patient were performed by anesthesiologists who were not involved in the study according to their preferences as part of the routine. The researchers were not involved in any intervention performed on the patient, only the data were recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group K | Those who have been administered ketamine for perioperative sedation | ||
| Group D | Those who have been administered dexmedetomidine for perioperative sedation. |
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| Measure | Description | Time Frame |
|---|---|---|
| Mini-Mental Status Test | Evaluation of the effect of sedation with ketamine and dexmedetomidine on postoperative cognitive functions by Mini-Mental Status Test | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| noninvasive mean arterial pressure | The effect of sedation on perioperative hemodynamics. | 6 months |
| The heart rate | The effect of sedation on perioperative hemodynamics. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients sedated with ketamine and dexmedetomidine during spinal anesthesia for hip fracture
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| Name | Affiliation | Role |
|---|---|---|
| Derya A Yurtlu, M.D. | Izmir Katip Celebi University Atatürk Training and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Izmir Katip Çelebi University Atatürk Training and Research Hospital | Izmir | 35360 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41917926 | Derived | Cetinkaya AS, Yurtlu DA, Tuzen AS. The effect of sedation methods on early postoperative cognitive decline in patients undergoing hip fracture surgery with spinal anesthesia: a prospective cohort study. BMC Surg. 2026 Apr 1;26(1):324. doi: 10.1186/s12893-026-03706-5. |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D005264 | Femoral Fractures |
| D006620 | Hip Fractures |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D050723 | Fractures, Bone |
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| 6 months |
| D014947 |
| Wounds and Injuries |
| D007869 | Leg Injuries |
| D025981 | Hip Injuries |