Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
To evaluate the efficacy of the intervention in improving Motivation.
To evaluate the efficacy of the intervention in improving Fatigue, Motivation/Vigor, Focus/Sustained Attention and blood levels of B vitamins and taurine.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Investigational Product (Capsules with B vitamins & taurine) | Experimental | IP will be administered orally once daily in capsule form, ideally between conventional mealtimes (i.e., breakfast, lunch, supper). |
|
| Microcrystalline cellulose placebo | Placebo Comparator | Placebo will be administered orally once daily in identical capsule form as the IP, ideally between conventional mealtimes (i.e., breakfast, lunch, supper). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Capsules with B vitamins & taurine | Dietary Supplement | Administered orally in a span of 28 days between mealtimes |
|
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the efficacy of the intervention in improving Motivation | The mean change from baseline to day 28 of product intake across sessions in the Monetary Incentivized Delay Task (MIDT). Assessment will be recorded as number of success over total in fraction or in % | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the efficacy of the intervention in improving Fatigue. | Profile of Mood States short-form 2 (POMS-SF 2): change in self-reported levels of fatigue/inertia. Assessment will be recorded as score in arbitrary units (A.U.) | 28 days |
| To evaluate the efficacy of the intervention in improving Fatigue. |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the effect of the intervention on blood levels of vitamins B6 & B9 | Change in level of vitamins B6 & B9 in blood at baseline and Day 28 of each administration period. Assessment will be recorded in microgram per litre (µg/L). | 28 days |
| To evaluate the effect of the intervention on blood levels of vitamins B12 |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Veeda M Anlacan, MD | University of the Philippines | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Philippine General Hospital | Philippines | 1004 | Philippines |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41889717 | Derived | Anlacan VM, Jamora RDG, Krattinger LF, De Longis E, Hartweg M, Steinmann M, Trovo L. A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial. Front Nutr. 2026 Mar 11;13:1711478. doi: 10.3389/fnut.2026.1711478. eCollection 2026. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D013654 | Taurine |
| ID | Term |
|---|---|
| D017738 | Alkanesulfonic Acids |
| D000473 | Alkanes |
| D006839 | Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
Not provided
Not provided
Randomized, double-blind, placebo-controlled, 2-arm, cross over trial. Participants will receive both the investigational product and placebo, each administered separately for a duration of 28 days, separated by a washout period of 28 days.
Not provided
Not provided
Not provided
| Microcrystalline cellulose placebo | Other | Administered orally in a span of 28 days between mealtimes |
|
NASA Task Load Index (NASA-TLX): changes in self-reported levels of perceived mental, physical, and temporal demands, self-perceived overall performance, levels of perceived effort exertion and levels of frustration. Assessment will be recorded as score in arbitrary units (A.U.) |
| 28 days |
| To evaluate the efficacy of the intervention in improving Focus | Capacity to sustain high levels of attention: Psychomotor Vigilance Task. Assessment will be recorded as total number of lapses in absolute number. | 28 days |
| To evaluate the efficacy of the intervention in improving Vigor. | POMS-SF 2: change in self-reported levels of vigor. Assessment will be recorded as score in arbitrary units (A.U.) | 28 days |
| To evaluate the efficacy of the intervention in improving Focus | Capacity to sustain high levels of attention: Psychomotor Vigilance Task. Assessment will be recorded as reaction time in milisecond (ms) | 28 days |
| To evaluate the efficacy of the intervention in improving Motivation | The mean change from baseline to day 28 of product intake across sessions in the Monetary Incentivized Delay Task (MIDT). Assessment will be recorded as effort or force in kilogram-force (kgf) | 28 days |
| To evaluate the efficacy of the intervention in improving Vigor. | Self-reported motivation with the Global Motivation Scale: changes in intrinsic motivation, extrinsic motivation, and amotivation. Assessment will be recorded as score in arbitrary units (A.U.) | 28 days |
Change in level of vitamin B12 in blood at baseline and Day 28 of each administration period. Assessment will be recorded in nanograms per litre (ng/L). |
| 28 days |
| To evaluate the effect of the intervention on blood levels of taurine | Change in level of taurine in blood at baseline and Day 28 of each administration period. Assessment will be recorded in micromoles per litre (µmol/L) | 28 days |
| D009930 |
| Organic Chemicals |
| D013451 | Sulfonic Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |