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Early-stage non small cell lung cancer represents 20-30% of all non small cell lung cancer and is characterized by a high survival probability after surgical resection. However, considering stage IA-IIIA non small cell lung cancer, a relapse rate of about 50% is observed, with a different survival probability on the basis of tumor node metastasis status, although patients within the same tumor node metastasis stage exhibit wide variations in recurrence rate. There are currently no validated prognostic biomarkers able to identify patients with a high risk of relapse.
This study will use data from an already available cohort of patients enrolled in the Resting study (a project funded by TRANSCAN in 2018) as a training set and data from a new concurrent cohort as validation set.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resected early stage non small cell lung cancer | Early stage (IA-IIIA) resectable non small cell lung cancer patients receiving surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resected non small cell lung cancer | Other | plasma sample, tissue sample and computed tomography scan images |
|
| Measure | Description | Time Frame |
|---|---|---|
| Algorithm for disease free survival | Analysis on a training cohort of resected early-stage non small cell lung cancer | 18 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patient with an early stage of non small cell lung cancer with an indication of surgical resection
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Julien MAZIERES, MD, PhD | Contact | 0567771837 | 33 | mazieres.j@chu-toulouse.fr |
| Name | Affiliation | Role |
|---|---|---|
| Julien MAZIERES, MD, PhD | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Julien MAZIERES | Recruiting | Toulouse | 31059 | France |
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| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
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biomarkers detected on plasma and tissue samples for analysis of circulating and extracellular vesicles-derived microRNAs as well as of free circulating DNA performed
| D013899 |
| Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |