The intraoperative blood pressure changes have been important for postoperative morbidity and mortality. However, some patients did not occur intraoperative hypotension but some patients would have severe intraoperative hypotension. It may be associated with genome related. In this hypothesis, we aim to elucidate the association between the whole exome genome and intraoperaive blood pressure changes.

We aim to elucidate the association between the whole exome genome and intraoperative blood pressure changes.

We will enroll patients older than 20 years old and undergo elective general anesthesia.

Before anesthesia, we will obtain blood sample for whole exome genome test and give arterial line for intraoperative monitor.

After completing surgery, we will follow the patients' all postoperative major organ function.

We hope this study to be able to give us the more information about the specific genetic effect on the arterial stiffness and intraoperative blood pressure changes.

Inclusion Criteria:

• elective general surgery

Exclusion Criteria:

• coagulopathy

patients recieving general anesthesia

due to ethical concern