Correlation Between Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy

Correlation Between Early Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy

The purpose of this study was to explore the relationship between early myocardial injury caused by tumor drug therapy and intestinal microbial structure changes by echocardiographic two-dimensional speckle tracking technique and intestinal microflora structure detection.

This is a monocentric prospective cohort study in which 50 patients treated for malignant tumors will be included. All participants will be followed for 6 months after the initiation of oncology drug therapy. Echocardiography and 2D speckle tracking will be performed and stool and blood samples will be tested before treatment initiation and at 3 and 6 months after initiation.

Inclusion Criteria:

• With malignant tumors
• Will receive antitumor drugs
• Could receive regular follow-up for 6 months
• Written informed consent

Exclusion Criteria:

• Satisfactory echocardiographic images could not be obtained
• Cardiomyopathy
• Coronary artery disease
• Heart failure
• Arrhythmia requiring intervention
• Moderate or severe valvular disease
• Acute myocarditis
• Refractory hypertension
• Participating in other studies of drug intervention