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In this randomized controlled trial the effect of 4 months of multi-component (strength, balance, cognition, endurance) exercise training intervention on measures of neuromuscular performance, cognition, and endurance as well as neural adaptations on a central and peripheral level is investigated. 40 subjects are recruited that are generally health and between 60 and 80 years of age. The interventions is based around exercises, where different tasks have to be solved simultaneously rather than serially, as has previously been done.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Agility Training | Experimental | 16 weeks, two times per week, 1 hour of multi-component exercise training, exercise guidelines and exercise diary. |
|
| Control | Active Comparator | Exercise guidelines and exercise diary. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Agility training | Behavioral | Multi-component (strength, balance, cognition) exercise training. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Isometric knee-extension strength | Strength in torque (N*m) of the quadriceps femoris muscle. Measured on an isokinetic device in an isometric condition. | 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Isometric knee-flexion strength | Strength in torque (N*m) of the hamstring muscle group measured on an isokinetic device in an isometric condition. | 16 weeks |
| Cognitive Processing Speed | Eriksen flanker task performance measured be reaction speed in milliseconds and accuracy in percentage. |
| Measure | Description | Time Frame |
|---|---|---|
| Corticospinal Inhibition | Difference between paired and single pulse motor evoked potential by transcranial magnetic stimulation. | 16 weeks |
| Voluntary activation | Degree of ability to contract the soleus muscle voluntarily. |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Departement für Sport, Bewegung und Gesundheit | Basel | Canton of Basel-City | 4052 | Switzerland |
Publication of the raw data along the publication of the results. Data is anonymized. Outcome results of the individual tests are shared.
End of 2023
Open Access
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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Randomized controlled trial with an intervention and a control arm.
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Due to the nature of the study (exercise intervention) no masking of participants and intervention providers is possible.
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| Exercise recommendations | Behavioral | Participants are being given the standard recommendations how much exercise and what type older adults should do. |
|
| Exercise diary | Behavioral | Participants are instructed to write down their physical activity and exercises. |
|
| 16 weeks |
| Cognitive Impulsiveness | Go / No-Go task performance measured by reaction speed in milliseconds and accuracy in percentage. | 16 weeks |
| Balance Performance | Staying as stable as possible during ten seconds in tandem stance eyes open condition. Center of pressure sway path length in mm and average sway speed in m/s is calculated. | 16 weeks |
| Hand Grip Strength | Using a handheld dynamometer with an extended arm squeezing as hard as possible. Measured in N. | 16 weeks |
| Counter movement jump power | Measured on a force plate participants are instructed to jump as high as possible with their hands akimbo. Peak of the time-power curve in Watts. | 16 weeks |
| Blood Pressure | Blood pressure cuff on the right arm at the height of the aorta. Measured in mmHG. | 16 weeks |
| Pulse Wave Velocity | Estimated from a mobile blood pressure cuff (mobil-O-graph) on the right arm. Measured in m/s. | 16 weeks |
| Retinal vessel diameter | A photo is made from the retinal vessels with a static vessel analyzer (camera)through the eye and the vessel diameters are measured in mikrometers. | 16 weeks |
| Quality of Life Questionnaire | 26 item questionnaire (WHOQOL-Bref). Every answer is rated on a scale from 1 to 5. Aggregate Score from 0 to 100. | 16 weeks |
| Fall Efficacy | 16 item qestionnaire (Fall Efficacy Scale). Every answer is rated on a scale from 1 to 4. | 16 weeks |
| Sleep Disturbances | 7 item questionnaire (Insomnia Severity Index). Every answer is rated on a scale from 1 to 5. | 16 weeks |
| Stress | 10 item qestionnaire (Perceived Stress Scale). Every answer is rated on a scale from 1 to 5. | 16 weeks |
| Depression | 15 item questionnaire (Center for Epidemiological Studies Depression Scale). Every answer is rated on a scale from 1 to 4. | 16 weeks |
| 16 weeks |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |