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| Name | Class |
|---|---|
| Seoul National University | OTHER |
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This study will compare the analgesic efficacy of daily single-shot adductor canal block(ABC) versus continuous ACB after total knee arthroplasty (TKA).
Patients 19-75 years old, of ASA classification I-III scheduled for unilateral TKA, will be enrolled and randomized into two groups, single-shot ACB group and continuous ACB group. In both groups, participants will be administered a single-shot ACB immediately after the end of the operation. The single-shot ACB group will receive two separate single-shot ACBs, on the first and second postoperative day. A nerve block catheter will be placed in patients in the continuous ACB group, which will be connected to a patient-controlled analgesia pump until the second postoperative day. The primary outcome of this study is the average NRS pain score at rest from the end of surgery to 2 days after surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single shot adductor canal block | Experimental |
| |
| Continuous adductor canal block | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Single shot adductor canal block | Procedure | Single shot adductor canal block on the the first and second postoperative day. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Average NRS pain score at rest | average of numerical rating scale (0: no pain, 10: worst imaginable pain) pain scores from 8 time points during 48h (+4h, +8h, +12h from end of surgery, 6AM, 2PM, 10PM of postoperative day 1, and 6AM and 2PM of postoperative day 2) | first 48h after end of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score at rest at +4h from end of surgery | +4h from end of surgery | |
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at +4h from end of surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Seokha Yoo, MD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 03080 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39964911 | Derived | Kim H, Yoo S, Kwon S, Kim Y, Bae J, Kim YJ, Cho YJ, Kim JT, Lim YJ. Analgesic Efficacy of Repeated Daily Injections Versus Continuous Adductor Canal Block After Total Knee Arthroplasty: An Open-Label, Randomized Clinical Trial. Anesth Analg. 2026 Jan 1;142(1):132-139. doi: 10.1213/ANE.0000000000007427. Epub 2025 Feb 18. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| Continuous adductor canal block | Procedure | A catheter will be placed in the adductor canal and connected to a continuous patient-controlled analgesia pump. |
|
| +4h from end of surgery |
| NRS pain score at rest at +8h from end of surgery | +8h from end of surgery |
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at +8h from end of surgery | +8h from end of surgery |
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score at rest at +12h from end of surgery | +12h from end of surgery |
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at +12h from end of surgery | +12h from end of surgery |
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score at rest at 6AM on postoperative day 1 | 6AM on postoperative day 1 |
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at 6AM on postoperative day 1 | 6AM on postoperative day 1 |
| NRS pain score at rest at 2PM on postoperative day 1 | 2PM on postoperative day 1 |
| NRS pain score during movement at 2PM on postoperative day 1 | 2PM on postoperative day 1 |
| NRS pain score at rest at 10PM on postoperative day 1 | 10PM on postoperative day 1 |
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at 10PM on postoperative day 1 | 10PM on postoperative day 1 |
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score at rest at 6AM on postoperative day 2 | 6AM on postoperative day 2 |
| NRS pain score during movement at 6AM on postoperative day 2 | 6AM on postoperative day 2 |
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score at rest at 2PM on postoperative day 2 | 2PM on postoperative day 2 |
| numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at 2PM on postoperative day 2 | 2PM on postoperative day 2 |
| Posteoperative opioid administration in morphine equivalents | from end of surgery to 48h after surgery |
| Incidence of catheter tip dislocation | The catheter tip is considered to be dislocated if the catheter tip is located outside the adductor canal | at 2PM on postoperative day 1 and 2 |
| Incidence of extravasation from catheter insertion site | at 2PM on postoperative day 1 and 2 |
| Incidence of sleep disturbance due to pain | from end of surgery to postoperative day 2 |
| Incidence of numbness of anterior thigh area | at 2PM on postoperative day 1 and 2 |
| Strengh of quadratus femoris muscle (unit: kgf) | at 2PM on postoperative day 1 and 2 |
| Incidence of falls during hospital stay | from end of surgery to 48h after surgery |
| Postoperative range of motion of knee joint | at 2PM on postoperative day 1 and 2 |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |