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The primary aim of this work is to evaluate the role of high frequency oscillatory ventilation (HFOV) in recruitment of lung in preterm newborns 32 to 37 weeks gestational age with moderate to severe respiratory distress. The secondary aim is to evaluate the role of chest ultrasound in monitoring of lung recruitment in comparison to routine chest x ray in those babies. Also cardiac hemodynamics will be assesed using functional echocardiography.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lung recruitment | Experimental | preterm infants with moderate to severe respiratory distress |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lung recruitment | Other | establishment of lung recruitment using high frequency ventilation and assessment with chest ultrasound and echocardiography |
|
| Measure | Description | Time Frame |
|---|---|---|
| chest US | A mobile device (PHILIPS ® HD11 XE) with a 10-MHz linear probe will be used for chest ultrasound the 12 lung zones will be assessed regarding
| first 3 days after birth |
| Superior Vena Cava flow in ml/kg/min | Superior Vena Cava (SVC) Blood Flow using functional echocardiography | first 3 days of life |
| estimated pulmonary artery pressure in mmHg | Pulmonary artery pressure (PAP) will be assessed by measuring tricuspid valve regurgitation peak velocity: this will be measured in apical 4 chamber view, with continous wave Doppler using modified Bernoulli equation. Systolic pulmonary artery pressure is equivalent to right ventricular systolic pressure in absence of outflow obstruction. Systolic Pulmonary Artery Pressure (SPAP) = Right Ventricular Systolic Pressure = 4x TR2 + Right Atrial Pressure (RAP), with RAP= 3-5 mmHg. | first 3 days of life |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marwa M Farag, PhD | Contact | 01288681788 | +2 | d.marwa.farag@gmail.com |
| Mohamed Hany Saad, MBBCh | Contact | 01282226826 | +2 | mohamedhany_90@icloud.com |
| Name | Affiliation | Role |
|---|---|---|
| Mohamed Hazem Wagih Gouda, PhD | Alexandria University | Study Chair |
| Ali Mohamed Abd Almohsen, PhD | Alexandria University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Marwa Mohamed Farag | Recruiting | Alexandria | 0325 | Egypt |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| Neonatal Intensive Care Unit (NICU) of Alexandria University Maternity Hospital. | Not yet recruiting | Alexandria | 21131 | Egypt |
|
| D000091642 | Urogenital Diseases |