Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| University of Milan | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this clinical trial is to evaluate regional ventilation distribution in patients admitted to the intensive care unit after emergent laparotomy due to abdominal sepsis. The main question it aims to answer is:
• evaluate if patients admitted after an open abdomen strategy have a different regional ventilation distribution compared to patients in which abdomen is closed at the end of the procedure
Participants will undergo non-invasive monitoring (esophageal pressure and electrical impedance tomography) and an blood gas analysis samples.
Researchers will compare open abdomen group and closed abdomen group to see if the ventilation distribution pattern is different.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Open Abdomen | Other |
| |
| Closed Abdomen | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Arterial blood gas analysis | Diagnostic Test | The researches will collect 2 ml of arterial blood using an arterial line already in place for clinical purposes to perform and arterial gas analysis. |
| Measure | Description | Time Frame |
|---|---|---|
| Chest-wall compliance (Ccw) measured using respiratory parameters from the Ventilator | Different chest wall compliance between the two groups measured using the esophageal catheter. Chest wall compliance will be calculated using the data provided from the respiratory monitoring (i.e. esophageal balloon catheter). | Day 0 |
| Chest-wall compliance (Ccw) measured using respiratory parameters from the Ventilator | Different chest wall compliance between the two groups measured using the esophageal catheter. Chest wall compliance will be calculated using the data provided from the respiratory monitoring (i.e. esophageal balloon catheter). | Day 1 |
| Chest-wall compliance (Ccw) measured using respiratory parameters from the Ventilator | Different chest wall compliance between the two groups measured using the esophageal catheter. Chest wall compliance will be calculated using the data provided from the respiratory monitoring (i.e. esophageal balloon catheter). | Day 2 |
| Measure | Description | Time Frame |
|---|---|---|
| Regional ventilation distribution measured using Electrical impedance tomography | The researchers will evaluate differences in ventilation distribution pattern among the different weaning trials using Electrical Impedance Tomography and focusing on: Regional ventilation distribution Regional inhomogeneity Regional compliance distribution Center of Ventilation Regional ventilation delay Regional compliance |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gaetano Scaramuzzo | Contact | 0532238108 | +39 | scrtn@unife.it |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azienda Ospedaliero Universitaria Sant'Anna | Ferrara | 44121 | Italy |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Venous blood gas analysis | Diagnostic Test | The researches will collect 2 ml of arterial blood using a central venous line already in place for clinical purposes to perform a gas analysis. |
|
| Esophageal pressure monitoring | Diagnostic Test | The researchers will position an esophageal balloon to evaluate esophageal pressure |
|
| Intrabdominal pressure | Diagnostic Test | The researches will assess intrabdominal pressure using the urinary catheter system already in place for clinical purposes . |
|
| Electrical impedance tomopgraphy | Diagnostic Test | The researches will evaluate regional ventilation distribution using Electrical impedance tomography at different levels of positive end-expiratory pressure |
|
| Day 0 |
| Regional ventilation distribution measured using Electrical impedance tomography | The researchers will evaluate differences in ventilation distribution pattern among the different weaning trials using Electrical Impedance Tomography and focusing on: Regional ventilation distribution Regional inhomogeneity Regional compliance distribution Center of Ventilation Regional ventilation delay Regional compliance | Day 1 |
| Regional ventilation distribution measured using Electrical impedance tomography | The researchers will evaluate differences in ventilation distribution pattern among the different weaning trials using Electrical Impedance Tomography and focusing on: Regional ventilation distribution Regional inhomogeneity Regional compliance distribution Center of Ventilation Regional ventilation delay Regional compliance | Day 2 |
| Mortality in the intensive care unit | Mortality rate in ICU | Up to 28 days |
| Infection rate during ICU stay | New diagnosis of infections during the ICU stay | Up to 28 days |
| ID | Term |
|---|---|
| D059413 | Intraabdominal Infections |
| D004630 | Emergencies |
| ID | Term |
|---|---|
| D007239 | Infections |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D001784 | Blood Gas Analysis |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D008919 | Investigative Techniques |
Not provided
Not provided