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| ID | Type | Description | Link |
|---|---|---|---|
| 22/LO/0808 | Other Identifier | REC Reference |
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| Name | Class |
|---|---|
| Imperial College London | OTHER |
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Breath and sweat samples will be collected from people who have been admitted to hospital after a potential seizure and analysed by the team. The researchers then hope to identify a pattern of small molecules that can distinguish seizures from other events, and perhaps determine the severity of the seizure.
Determining whether someone has had an epileptic seizure, or another event, can be challenging and result in the wrong diagnosis. A 'seizure test' used after the event would therefore be very helpful.
Researchers have used small molecules released from the body in breath and sweat to detect cancers and other diseases; this study will determine whether a similar method can be used to detect whether someone has had an epileptic seizure.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sample Collection | Other | Patients will have breath samples collected by blowing into a bag, and sweat samples collected by gauze. These samples will be collected at various timepoints whilst the patients are admitted on the ward. |
| Measure | Description | Time Frame |
|---|---|---|
| Distinguishing epileptic from non-epileptic seizures | To distinguish epileptic from non-epileptic seizures with the detection of volatile organic compounds (VOCs) in breath and sebum samples. | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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People with a diagnosis of epileptic or non-epileptic seizures
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Eleonora Lugara, PhD | Contact | 02031089108 | e.lugara@ucl.ac.uk | |
| Grace Luff, MSc | Contact | g.luff@ucl.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Matthew Walker, MB BChir FRCP | Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chalfont Centre for Epilepsy | Recruiting | London | Buckinghamshire | SL9 0RJ | United Kingdom |
If necessary, anonymised data will be shared with other researchers in a case by case scenario. For anonymised data to be shared with commercial entities, a research contract will need to be evaluated.
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| D012640 | Seizures |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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| National Hospital for Neurology and Neurosurgery | Recruiting | London | London | WC1N 3BG | United Kingdom |
|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |