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| Name | Class |
|---|---|
| General and Pancreatic Surgery Unit, University of Verona | UNKNOWN |
| Fondazione Valsecchi | UNKNOWN |
| Associazione Oltre La Ricerca | UNKNOWN |
| Genomica srl |
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The goal of the PROPH-ITA Study is to perform genetic testing in family members of pancreatic cancer patients who may have a genetic predisposition. The subjects belong to the Italian Registry of Families At Risk of Pancreatic Cancer (IRFARPC, #NCT04095195). This investigational study will assess the genetic background of subjects with familiarity with pancreatic cancer only.
Participants may accept to undergo genetic testing as part of the IRFARPC registry, through a saliva-swab-based 41-gene panel test.
Up to 3,000 participants will be enrolled in this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Saliva testing swab | Other | Subjects with familiarity with pancreatic cancer enrolled into the IRFARPC registry (NCT04095195) will be submitted to buccal swab for saliva-based genetic testing |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Saliva swab testing | Genetic | 41 pancreatic cancer predisposition genes will be tested through a saliva-based swab |
|
| Measure | Description | Time Frame |
|---|---|---|
| Presence - absence of predisposing mutations | Prevalence of genetic mutations over the total tested | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of genetic mutations with personal oncological history | Correlation between presence of predisposing mutation and prevalence of cancers | 5 years |
| Correlation of genetic mutations with familial oncological history |
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Inclusion Criteria:
Exclusion Criteria:
- Already known genetic mutation
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Erica Secchettin, PharmD | Contact | 0458126254 | familiarita.aisp@gmail.com | |
| AISP Association | Contact | 340 2713112 | aisp.ricerca@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chirurgia generale e del Pancreas Azienda Ospedaliera Universitaria Integrata | Recruiting | Verona | 37136 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41691430 | Derived | Paiella S, Secchettin E, Archibugi L, De Luca R, Bonifacio C, Laghi L, Lionetto G, Milanetto AC, Sereni G, Coluccio C, Lauri G, Dal Buono A, Patruno M, Gabriel G, Sassatelli R, Binda C, Bonvissuto D, Uliana V, Malleo G, Cavestro GM, Terrin M, Martino S, Pasquali C, De Pastena M, De Cobelli F, Poletti V, Venturini E, Puzzono M, Zerbi A, Arcidiacono PG, Salvia R, Falconi M, Capurso G, Carrara S. Discovering Hereditary Risk Through Surveillance: A Prospective Genetic Analysis of Individuals With Familial Pancreatic Cancer. United European Gastroenterol J. 2026 Feb;14(1):e70187. doi: 10.1002/ueg2.70187. |
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| ID | Term |
|---|---|
| D010190 | Pancreatic Neoplasms |
| D020022 | Genetic Predisposition to Disease |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
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| UNKNOWN |
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Correlation between presence of predisposing mutation and prevalence of cancers in the family
| 5 years |
| D004066 |
| Digestive System Diseases |
| D010182 | Pancreatic Diseases |
| D004700 | Endocrine System Diseases |
| D004198 | Disease Susceptibility |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |