Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study is to evaluate the recovery of diaphragm function and atelectasis after reversal of neuromuscular blockade with Neostigmine and Sugammadex using lung ultrasound and diaphragm ultrasound for children aged 2 to 7 who are scheduled for the surgical procedure under general anesthesia.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neostigmine | Active Comparator | The use of neostigmine 0.02mg/kg for reversal of neuromuscular blocking agent. |
|
| Sugammadex | Experimental | The use of sugammadex 2mg/kg for reversal of neuromuscular blocking agent. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sugammadex | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Diaphragm excursion ratio | The ratio of diaphragm excursion at the time before injecting neuromuscular blocking agent before surgery (T0) and diaphragm excursion at the time after reversal of neuromuscular blocking agent (T1) | during diaphragm ultrasound procedure after reversal of neuromuscular blocking agent (T1), an average of 10 minute |
| Measure | Description | Time Frame |
|---|---|---|
| modified lung ultrasound score before neuromuscular blockade (LUS_T0) | Both lung ultrasound score can be calculated by adding up the 12 individual pulmonary quadrant scores yielding a score between 0 (no aeration loss) and 36 (complete aeration loss) | during lung ultrasound procedure before neuromuscular blocking agent (T0), an average of 10 minutes |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | Jongrogu | 03080 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40625141 | Derived | Park JB, Kim TW, Ji SH, Jang YE, Kim EH, Kim JT, Kim HS, Lee JH. Ultrasonographic assessment of sugammadex-enhanced early recovery of diaphragmatic function in children: A randomised double-blind controlled trial. Eur J Anaesthesiol. 2025 Oct 1;42(10):907-915. doi: 10.1097/EJA.0000000000002231. Epub 2025 Jul 7. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D055191 | Delayed Emergence from Anesthesia |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D000077122 | Sugammadex |
| D009388 | Neostigmine |
| ID | Term |
|---|---|
| D047408 | gamma-Cyclodextrins |
| D003505 | Cyclodextrins |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Neostigmine | Drug |
|
|
|
| modified lung ultrasound score after reversing neuromuscular blockade (LUS_T1) | Both lung ultrasound score can be calculated by adding up the 12 individual pulmonary quadrant scores yielding a score between 0 (no aeration loss) and 36 (complete aeration loss) | during lung ultrasound procedure after reversing neuromuscular blocking agent(T1), an average of 10 minutes |
| modified lung ultrasound score at post-anesthesia care unit (PACU) (LUS_T2) | Both lung ultrasound score can be calculated by adding up the 12 individual pulmonary quadrant scores yielding a score between 0 (no aeration loss) and 36 (complete aeration loss) | 30 minutes after entering the post-anesthesia care unit (T2) |
| total recovery time (sec) | time from injection of a neuromuscular block reversal agent to extubation | From injection of neuromuscular block reversal agent to extubation, not to exceed 20 minutes |
| perioperative respiratory adverse events | laryngospasm, bronchospasm, desaturation (SpO2 < 95%), airway obstruction, severe coughing, postoperative stridor during the emergence period | intraoperative |
| length of stay in post-anesthesia care unit | Length of stay in post-anesthesia care unit | from entering the post-anesthesia care unit to discharge from the post-anesthesia care unit, up to 24 hours |
| Adverse events occurred during post-anesthesia care unit stay | agitation, stridor, desaturation (SpO2<95%), nausea, vomiting, bradycardia, somnolence, need for oxygen support | from entering the post-anesthesia care unit to discharge from the post-anesthesia care unit, up to 24 hours |
| postoperative pulmonary complication | pneumonia, respiratory failure, pleural effusion, atelectasis described in postoperative chest radiography, pneumothorax, bronchospasm, aspiration pneumonia | from entering the general ward after surgery to discharge from hospital, up to 7 days |
| D003912 |
| Dextrins |
| D013213 | Starch |
| D005936 | Glucans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
| D050338 | Phenylammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D009861 | Onium Compounds |