During the last twenty years, the cancer overall incidence has been increasing in europe and developed countries, while diagnostic and therapeutic progress have contributes to a reduction in mortality. Currently, almost 4 million people are treated or followed for cancer in France. The physical, psychological and social after-effects are significant.

Adaptated physical activity plays an important role in the rehabilitation process. Overall, meta-analyses carried-out with most frequent cancers demonstrate that physical activity practiced would allow an improvement in quality of life, tolerance to anticancer treatments and survival.

This is a multicenter, two-arm parallel-group randomizes (in a 1:1 ratio), open-label, controlled intervention clinical trial of the comparison of long term adherence to physical activity between an adaptative, customized and collaborative exercise program and standard exercise prescription in patients with newly diagnosed cancer.

Inclusion Criteria:

• newly-diagnosed cancer patient
• able to start a program of physical activity within the first year follow diagnosis
• performance status between 0 to 2

Exclusion Criteria:

• uncontrolled cardiovascular disease
• peripheral neuropathy grade 3-4 with risk of falling
• bone metastasis with risk of bone fracture
• platelets <100X109/L
• hemoglobin <8g/dL
• patient under legal protection