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The goal of this clinical trial is to Evaluating Metformin Efficacy and Safety when Co-administered with Antiepileptic Drugs in Patients with Seizures. The main question it aims to answer is:
Participants will be divided into 2 groups (control group and treatment group)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group (+ve control) | Active Comparator | levetiracetam &/or sodium valproate |
|
| Treatment group | Experimental | metformin + (levetiracetam &/or sodium valproate) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Levetiracetam &/or sodium valproate | Drug | levetiracetam &/or sodium valproate will be given to 30 patients and monitored for 6 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Seizures Frequency | will be recorded using seizures diary. | 6 months |
| Seizures Severity | will be measured using chalfont seizures severity scale. | 6 months |
| Quality of Life level | will be recorded using SF-36 health survey. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in BMI | 6 months | |
| Change in biological markers | eg. serum lactate. | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Omnia Ashraf Abd El Aziz Ahmed Kotb | Alexandria | Egypt |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000077287 | Levetiracetam |
| D014635 | Valproic Acid |
| D008687 | Metformin |
| ID | Term |
|---|---|
| D000081 | Acetamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000085 | Acetates |
| D000144 |
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|
| Metformin | Drug | metformin + (levetiracetam &/or sodium valproate) will be given to 30 patients and monitored for 6 months will be given to 30 patients and monitored for 6 months |
|
| Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D011760 | Pyrrolidinones |
| D011759 | Pyrrolidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D010421 | Pentanoic Acids |
| D014631 | Valerates |
| D005232 | Fatty Acids, Volatile |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |