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The present study was designed to evaluate bowel function in preschool and early childhood in a large number of patients with anorectal Malformation and to identify the associated risk factors for bowel dysfunction.
Anorectal malformation (ARM) is a type of congenital malformation resulting from post-embryonic intestinal dysgenesis, occurring in about 1 in 5000 cases.Surgery is an effective means of treating ARM,which includes reconstruction of the anus and treatment of associated deformities. However, even with reconstruction of the anus, most children still have serious complications, such as constipation, fecal incontinence, urinary incontinence, and sexual dysfunction, in the mid-to-long postoperative period.A lot of studies have been designed to explore the trend toward normal bowel habits from preschool and early childhood age to adolescence or adult; however, no apparent improvement in bowel habits was completely confirmed. In contrast, many reports have shown that poor bowel function in preschool and early childhood may lead to social problems and depression in adolescence and adult.The reasons for bowel dysfunction of ARM in preschool and early childhood were complicated and undefined,including associated malformations, the type of ARM, and the development of the perianal sphincter,etc.The bowel function score (BFS) is currently used to assess mid- and long-term anal function in patients with ARM, and comprises seven major categories (e.g., self-perception, fecal control, stool collection, and social problems) with a total of 20 points, or less than 17 points, for the presence of anal weakness (11-17 points, for the general weakness, or less than 11 points, for the severe weakness) .Therefore,bowel function at preschool and early childhood should be evaluated in a large number of patients with ARM and the associated risk factors for bowel dysfunction should also be assessed. The present study was designed to evaluate bowel function in preschool and early childhood in a large number of patients with ARM and to identify the associated risk factors for bowel dysfunction using BFS.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bowel function score questionnaire survey | Other | Bowel function score(BFS, total 20 points) was approved by Rintala in 1995, and patients with a score ≥ 17 were considered to have normal bowel habits. 7 items were in BFS, including the ability to hold back defecation, feeling/reporting the urge to defecate, frequency of defecation, soiling, accidents, constipation. In December 2022, BFS questionnaire surveys were conducted on children with ARM who underwent surgical repair between January 2017 and December 2019 at Children's Hospital of Nanjing Medical University. |
| Measure | Description | Time Frame |
|---|---|---|
| bowel function score in partipants with ARM | approved by Rintala in 1995, and patients with a score ≥ 17 were considered to have normal bowel habits | through study completion, an average of 6 year |
| Measure | Description | Time Frame |
|---|---|---|
| Sacral ratio in partipants with ARM | test by X ray | through study completion, an average of 6 year |
| Measure | Description | Time Frame |
|---|---|---|
| Number of partipants with every type of ARM | confirmed in surgery | through study completion, an average of 6 year |
| age at surgery of partipants with ARM | age at surger |
Inclusion Criteria:
Anorectal malformation >4 years old
Exclusion Criteria:
Down syndrome patients <4 years
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Patients with ARM who were performed with surgery.The follow-up age was more than 4 years old.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Changgui Lu, Dr | Contact | 13770848448 | luchanggui1984@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Weibing Tang, Dr | Children's Hospital of Nanjing Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Hospital of Nanjing Medical University | Recruiting | Nanjing | Jiangsu | 210008 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37935997 | Derived | Lu C, Pan S, Chen H, Tang W. Bowel function and features of bowel dysfunction in preschool children with anorectal malformation type rectoperineal and rectovestibular fistula. Eur J Pediatr. 2024 Feb;183(2):599-610. doi: 10.1007/s00431-023-05306-4. Epub 2023 Nov 8. |
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| ID | Term |
|---|---|
| D007410 | Intestinal Diseases |
| D000071056 | Anorectal Malformations |
| ID | Term |
|---|---|
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D004065 | Digestive System Abnormalities |
| D000013 | Congenital Abnormalities |
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| through study completion, an average of 6 year |
| Number of partipants performed with every surgical method | Posterior sagittal approach to anoplasty or Anterior sagittal approach to anoplasty or Laparoscopic assisted anoplasty | through study completion, an average of 6 year |
| Number of partipants with abnormal spinal cord | tethered cord or other | through study completion, an average of 6 year |
| Number of partipants with reoperation | re-anoplasty | through study completion, an average of 6 year |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |