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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
| Imam Abdulrahman Bin Faisal University | OTHER |
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Gellan gum (GG) is a food grade polysaccharide produced by fermentation. In-vitro studies and in vivo pilot studies suggest that adding gellan gum to rice during cooking might reduce the extent of the increase in circulating blood glucose seen after its consumption (glycaemic response). This study will explore whether such a modification in response is sustained, particularly over a period of 7 days of consumption.
BACKGROUND: Rice is a carbohydrate-rich staple source of food for around half of the world population. Consumption is estimated to be 480 million tonnes per year. According to The Food and Agriculture Organization of the United Nations (FAO), rice is easily accessible to people in Asia, Pacific region, parts of Latin America and the Caribbean and, increasingly in Africa. Rice plays an important role in achieving an adequate dietary intake in these countries.
However high consumption of white rice has been linked with high obesity rates and increased risk for type 2 diabetes . However, it is still the favoured type of rice among consumers, contributing to the observed increasing trends in diet-related diseases in countries with high rice consumption . Modifying the properties of white rice products (e.g. reducing the glycaemic index and/or increasing satiety) with relatively simple interventions can contribute to producing foods that may promote better health due to modified digestion and post prandial metabolic and appetitive profiles. One way to reduce the glycaemic index of white rice may be the addition of hydrocolloids. These have previously been shown to modify the digestibility of foods . The health advantage derived from such modifications would be beneficial for consumers worldwide. Preliminary in-house in vitro digestion data suggested that the addition of gellan gum to rice cooking may reduce digestibility rates though mechanisms yet to be understood. Gellan gum (GG) "is a high molecular weight, water-soluble anionic, extracellular polysaccharide which is produced by the microorganism Sphingomonas elodea during fermentation". GG is commonly used as a gelling agent in foods. Gels formed by gellan gum have high resistance to acid, heat, and enzyme activity. The United States Food and Drug Administration (FDA) has approved the use of GG as a food additive for the human consumption (US.FDA, 2018). It is also approved by the European Community as a food additive with code (E-418). Gellan Gum is gluten free and broadly applied in gluten free foods to provide improved texture and good taste to pasta, biscuits, candy and dairy products. Therefore, it has been proved safe in the amounts the investigators intend to use, it is also suitable for people diagnosed with Coeliac disease as well as suitable for vegetarians, kosher and Halal diets, which make it acceptable for consumption and dietary intervention across different populations.
AIM: The overall purpose of this study is to explore the impact of cooking rice with gellan on the glycaemic and appetitive responses in healthy participants. Both the acute response to one meal will be considered, and the impact on the acute response having consumed the rice once a day over the preceding 7 days. Tolerance will also be considered.
HYPOTHESIS: This work will test the hypothesis that the addition of gellan gum to jasmine rice during cooking will reduce the post prandial glycaemic response. The investigators will also explore associated food intake, appetitive responses and tolerance during both the acute single meal exposure and over a 7 day period of consuming the same portion of rice each day, therefore testing the stability of the glycaemic and appetitive responses after a 7 day period of consumption. Establishing that any acute effect noted is sustained over a period of consumption will be important prior to recommending the addition of gellan to rice cooking as a therapeutic or public health strategy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gellan gum | Active Comparator | White rice test meal boiled in 356 g water containing 5.5g of gellan to each 185g of uncooked rice (50 g of available carbohydrate). Consumed on Day 1 at the study site, then consumed at home once daily for 7 days, then consumed again once at test site at Day 8 |
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| Control | Placebo Comparator | White rice test meal boiled in 356 g water without gellan gum (50 g of available carbohydrate). Consumed on Day 1 at the study site, then consumed at home once daily for 7 days, then consumed again once at test site at Day 8 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| White rice | Dietary Supplement | 185 g Jasmine (white) rice boiled in 356 g water |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Profile of post prandial 2 hour circulating blood glucose curve | Fingerprick blood glucose profile for 2 hours post consumption of test rice samples. | Over 2 hours post consumption |
| Measure | Description | Time Frame |
|---|---|---|
| Profile of post prandial 3.5 hour circulating blood glucose curve | Fingerprick blood glucose profile for 3.5 hours post consumption of test rice samples rs | Over 3.5 hours post consumption |
| Time to Peak of blood glucose |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Moira A Taylor, PhD | University of Nottingham | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Nottingham | Nottingham | Nottinghamshire | Ng7 2RD | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24708967 | Background | Garcia MC, Alfaro MC, Calero N, Munoz J. Influence of polysaccharides on the rheology and stabilization of alpha-pinene emulsions. Carbohydr Polym. 2014 May 25;105:177-83. doi: 10.1016/j.carbpol.2014.01.055. Epub 2014 Jan 27. | |
| 27314887 | Background | Azadbakht L, Haghighatdoost F, Esmaillzadeh A; New Collective Author. White Rice Consumption, Body Mass Index, and Waist Circumference among Iranian Female Adolescents. J Am Coll Nutr. 2016 Aug;35(6):491-499. doi: 10.1080/07315724.2015.1113902. Epub 2016 Jun 17. |
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Data sharing will be available after publication
After publication
Access on demand
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| ID | Term |
|---|---|
| C048288 | gellan gum |
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Randomised crossover placebo controlled
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| Gellan gum |
| Dietary Supplement |
Food grade hydrocolloid polysaccharide 5.5g dissolved in 356g cooking water containing 185g rice |
|
Fingerprick blood glucose time to peak
| Time period (during the 3.5 hour study period) until peak occurs in hours |
| Peak blood glucose | Fingerprick blood glucose peak value | During the 3.5 hour period of the study. |
| Appetite scores post prandial up to 3.5 hours up to 3.5 hours | Curve of Visual Analogue Scores up to 3.5 hours postprandially | Over 3.5 hours |
| Gastrointestinal tolerance scores up to 3.5 hours | Symptom scores up to 3.5 hours postprandially | Over 3.5 hours |
| Total amount of energy consumed on the first day | Food intake measured from food diaries | Over 24 hours |
| Explorative correlations | Explorative correlations between Fingerprick blood glucose area under the curve for 2 hours and 3.5 hours and respectively Area under the curve of appetite Visual Analogue Scores up to 2 hours and 3.5 hours postprandially | Over 2 hours and over 3.5 hours |
| Daily appetite scores measured using visual analogue scales | Appetite score recorded twice daily morning and evening for 7 days using 100mm visual analogue scales with a minimum value of 0mm and maximum value of 100mm. | Daily for 7 days |
| Gastrointestinal tolerance visual analogue scores questionnaire | Symptom scores measured daily over 7 days using 100mm visual analogue scales with 0mm as as the minimum and 100mm as the maximum. | Daily for 7 days |
| Gastrointestinal tolerance categorical questionnaire | Symptom scores measured daily over 7 days using categorial scores with 0 as as the minimum and 3 as the maximum. | Daily for 7 days |
| Daily total amount of energy consumed | Food intake measured from food diaries daily for 7 days | Daily for 7 days |
| 28137245 | Background | Golozar A, Khalili D, Etemadi A, Poustchi H, Fazeltabar A, Hosseini F, Kamangar F, Khoshnia M, Islami F, Hadaegh F, Brennan P, Boffetta P, Abnet CC, Dawsey SM, Azizi F, Malekzadeh R, Danaei G. White rice intake and incidence of type-2 diabetes: analysis of two prospective cohort studies from Iran. BMC Public Health. 2017 Jan 31;17(1):133. doi: 10.1186/s12889-016-3999-4. |
| 18359005 | Background | Mond JM, Myers TC, Crosby RD, Hay PJ, Rodgers B, Morgan JF, Lacey JH, Mitchell JE. Screening for eating disorders in primary care: EDE-Q versus SCOFF. Behav Res Ther. 2008 May;46(5):612-22. doi: 10.1016/j.brat.2008.02.003. Epub 2008 Feb 14. |
| 26770915 | Background | Yi Y, Jeon HJ, Yoon S, Lee SM. Hydrocolloids Decrease the Digestibility of Corn Starch, Soy Protein, and Skim Milk and the Antioxidant Capacity of Grape Juice. Prev Nutr Food Sci. 2015 Dec;20(4):276-83. doi: 10.3746/pnf.2015.20.4.276. Epub 2015 Dec 31. |