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This study aims to evaluate procedural and clinical outcomes of acute coronay syndrome (ACS) patients with aneurysmatic culprit right coronary artery (RCA).
The investigators sought differences in procedural (slow-flow, no-reflow, distal embolisation,Thrombolysis in Myocardial Infarction final flow (TIMI) etc.) and in immediate and long-term clinical outcomes between several subgroups such as index vs staged percutaneous coronary intervention (PCI), premedication vs none, use of IIb/IIIa inhibitors vs none, bare metal stent (BMS) vs drug eluting stent (DES), ultrathin DES vs thick DES, durable polymer vs bioresorbable or free polymer etc.
The investigators also want to investigate the efficacy of different technical manoeuvres involved in resolving high thrombotic burden before stent deployment, such as thrombus aspiration, dilatation, intracoronary infusion of adenosine or thrombolytic agents, direct stenting etc.). Long-term follow-up includes target vessel failure (Cardiac Death, target vessel MI, clinically-driven target vessel revascularisation), define or probable stent thrombosis, target vessel revascularisation for ACS, clinically driven target vessel revascularisation and intrastent restenosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Index PCI | Patients with an aneurysmatic right coronary artery undergoing index PCI in the acute setting. |
| |
| Staged PCI | Patients with an aneurysmatic right coronary artery undergoing staged PCI in the acute setting. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Percutaneous Coronary Intervention | Procedure | Treatment of coronary stenoses with a drug-eluting stent or balloon |
|
| Measure | Description | Time Frame |
|---|---|---|
| Technical success | Defined as final TIMI flow > 3 (TIMI 0: absence of any integrate flow beyond the coronary occlusion; TIMI 1: faint antegrade flow beyond the coronary occlusion with incomplete filling of the distal coronary bed; TIMI 2: delayed flow beyond the coronary occlusion with complete filling of the distal coronary bed; TIMI 3: normal flow with complete filling of the distal coronary bed) | Procedural (from the start to the end of the procedure) |
| Measure | Description | Time Frame |
|---|---|---|
| Target Lesion Failure | Combination of cardiac death, target vessel MI and clinically target lesion revascularization | 12 moths |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with aneurysmatic or ectatic right coronary artery disease in the acute setting following PCI.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Giulio Piedimonte, MD | Contact | +393201764900 | giulio.piedimonte@gmail.com | |
| Enrico Cerrato, MD | Contact | +393479317104 | enrico.cerrato@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ospedale Papa Giovanni XXIII | Recruiting | Bergamo | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39181812 | Derived | Piedimonte G, Cerrato E, Rolfo C, Nunez Gil IJ, Azzalini L, Mangione R, Maiellaro F, Boi A, Riganelli D, Sardone A, Bruno F, Scudiero F, Vizzari G, Carciotto G, Calderone D, Borgi M, Cancro FP, Sanchez I, Leoncini M, Sagazio E, Colombo F, Rosso G, Chechi T, Zecchino S, Pavani M, Franze A, Zanda G, Bosco M, Hernandez JMT, Micari A, Galasso G, Versaci F, Tamburino C, Patti G, La Manna A, Tomassini F, Varbella F. Percutaneous coronary interventions for aneurysmatic right coronary artery in acute coronary syndrome: RIGHTMARE registry outcomes. Cardiovasc Revasc Med. 2025 Jun;75:71-79. doi: 10.1016/j.carrev.2024.08.013. Epub 2024 Aug 22. |
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| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D003323 | Coronary Aneurysm |
| D000072657 | ST Elevation Myocardial Infarction |
| D054058 | Acute Coronary Syndrome |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D062645 | Percutaneous Coronary Intervention |
| ID | Term |
|---|---|
| D057510 | Endovascular Procedures |
| D014656 | Vascular Surgical Procedures |
| D013504 | Cardiovascular Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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| Azienda Ospedaliera Brotzu | Recruiting | Cagliari | 09047 | Italy |
|
| Policlinico Universitario G.Rodolico | Recruiting | Catania | 95123 | Italy |
|
| Azienda Ospedaliera Universitaria Gaetano Martino | Recruiting | Messina | 98124 | Italy |
|
| Ospedale Auxologico San Luca | Recruiting | Milan | Italy |
|
| Interventional Unit, San Luigi Gonzaga University Hospital, Orbassano, and Rivoli Hospital, Turin, Italy | Recruiting | Turin | 10100 | Italy |
|
| Ospedale Universitario Marqués de Valdecilla | Recruiting | Santander | Satander | 39008 | Spain |
|
| Hospital Clinico San Carlos | Recruiting | Madrid | Spain |
|
| D000783 |
| Aneurysm |
| D009203 | Myocardial Infarction |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D019060 | Minimally Invasive Surgical Procedures |