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The clinical trial studies the human pathogen of SARS-CoV-2, with a specificity in the circulating Spike 2 protein in the human system. The clinical trial hypothesizes that SARS-CoV-2 human pathogen arises from immune attacks, underlying the severe physiological symptoms that can be lethal. It further hypothesizes that the vaccines do not deal with the Spike 2 protein that causes the immune attacks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experiment Participant | Experimental | COVID-19 recombined vaccinated, 3 dose, no intervention. Nifedipine, oral, 30 mg per day for 2 days, active comparative. Angiotensin-converting enzyme inhibitor, oral, gradually increase to 20 mg per day at night. Beta blocker, oral, 23.75 - 95 mg per day in the morning. Proton-pump inhibitor, oral, 30 mg per day. Duloxetine hydrochloride, oral, placebo, 20 mg per day before sleep. Acetaminophen (sham comparator), oral, 250 mg four times per day for 8 days. Cefuroxime (sham comparator), oral, 100 mg twice per day for 6 days. Papaverine, oral, low-dosage in coughing pills for 4 days. Superoxide Dismutase (active comparator), oral, to be introduced. Bafilomycin A1 (active comparator), oral, 100 ug per kilogram per day, unlikely to be introduced for lack of funding. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nifedipine 30 MG | Drug | Due to initial availability of drugs and the intensities of the patient's symptoms, Nifedipine was used for initial intervention in preventing acute myocarditis from happening. |
| Measure | Description | Time Frame |
|---|---|---|
| Heart Rate | The heart rate is monitored daily, and the primary goal is to stabilize the patient's heart rate. | 1 day |
| Electrocardiogram | Electrocardiogram reflects the blood pressure management on the patient's health outcome and potential risks. | 20 days |
| Platelet Distribution | Platelet distribution is measured to determine the viral induced blood-borne pathogen in the physiological responses of the patient. | 10 days |
| Mean Platelet Volume | MPV is measured to determine the risks in blood clot and internal vein scratches in the patient. | 10 days |
| Eosinophil Absolute Number | Eosinophil Absolute Number is measured to determine the intensities of infection in the patient. | 10 days |
| Basophil Absolute Number | Basophil Absolute Number is measured on the counteraction of the patient's immune system integrities against the rapid acidification of the viral infection. | 10 days |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac Enzymes | Cardiac enzymes are measured to locate and eliminate the symptoms' causes, identify potential health risks, and to determine if subsidiary treatments are needed. | 10 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Residential Address | Chongqing | Chongqing Municipality | 402762 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35420469 | Background | Liu X, Mostafavi H, Ng WH, Freitas JR, King NJC, Zaid A, Taylor A, Mahalingam S. The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from Wuhan. mBio. 2022 Jun 28;13(3):e0068322. doi: 10.1128/mbio.00683-22. Epub 2022 Apr 14. | |
| 32287546 |
| Label | URL |
|---|---|
| B6.Cg-Tg(K18-ACE2)2Prlmn/J | View source |
| ID | Type | URL | Comment |
|---|---|---|---|
| 10.5281/zenodo.7534361 | Clinical Study Report | View IPD |
The emergent intervention started with the PI's research into the virology and post-vaccination adverse effects. The plan was improvised and adjusted accordingly. Statistical analysis was mainly physiological with relation to the virological inductions from the patient's symptomatic responses.
The first 20 days of data have been uploaded on Zenodo, and significant results and monitoring data will be updated accordingly.
The data is openly available on Zenodo. The hospital facility and personnel involved for prescription drugs and tests are deidentified.
| Type | Date | Date Unknown |
|---|---|---|
| Release | Feb 2, 2023 | |
| Reset | Mar 3, 2023 | |
| Release | Mar 5, 2023 |
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The crossover model intervenes on the precarditis and myocarditis happenings on the patient, and evaluates the cause of the symptoms. Basic medicines are tested against the pathogens with the immune responses of the patient.
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|
| Kangzhu BPCB0A-3A | Diagnostic Test | The diagnostic test has been used to confirm objective parameters to guide the intervention drug dosages and accessing the risks in sudden death and long term adverse effects. |
|
|
| Low Mobility | Behavioral | The behavioral intervention aimed at reducing the risks of sudden and strong blood flows in the patient's system. |
|
| Enalapril Maleate 10Mg Tab | Drug | The intervention aims to reduce the vein flows in Diastolic Blood Pressure, and the risks in blood clot formation and internal vein scratch bleeding. |
|
| Lansoprazole 30Mg Ec Cap | Drug | The intervention aims to server the allergy-inducing proteins to induce renal hemodialysis. |
|
| Metoprolol Succinate | Drug | Metoprolol Succinate is used to control the cardiac artery flow amounts and stabilize the patient's heart rate. |
|
| Coenzyme Q10 | Dietary Supplement | 200 mg per day is used for supplement with the cardiac interventions. |
|
| d-alpha tocopherol acetate | Dietary Supplement | The 268 mg twice per day dietary healthcare is the patient's usual daily use. |
|
| Omega-3 | Dietary Supplement | The 900 mg twice per day dietary healthcare is the patient's usual daily use. |
|
| Duloxetine Hydrochloride 20 MG Oral Capsule, Delayed Release | Drug | Duloxetine hydrochloride is used for the patient's neurodiverse conditions. |
|
|
| Superoxide Dismutase | Drug | Superoxide Dismutase is used to substitute the missing of antiviral drugs. |
|
| Wu Zhang X, Leng Yap Y. Structural similarity between HIV-1 gp41 and SARS-CoV S2 proteins suggests an analogous membrane fusion mechanism. Theochem. 2004 May;677(1):73-76. doi: 10.1016/j.theochem.2004.02.018. Epub 2004 Apr 2. |
| 33024307 | Background | Hu B, Guo H, Zhou P, Shi ZL. Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol. 2021 Mar;19(3):141-154. doi: 10.1038/s41579-020-00459-7. Epub 2020 Oct 6. |
| 33519802 | Background | Xavier LL, Neves PFR, Paz LV, Neves LT, Bagatini PB, Timmers LFSM, Rasia-Filho AA, Mestriner RG, Wieck A. Does Angiotensin II Peak in Response to SARS-CoV-2? Front Immunol. 2021 Jan 14;11:577875. doi: 10.3389/fimmu.2020.577875. eCollection 2020. |
| 29755512 | Background | Ortiz-Guerrero G, Amador-Munoz D, Calderon-Ospina CA, Lopez-Fuentes D, Nava Mesa MO. Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plast. 2018 Mar 21;2018:5257285. doi: 10.1155/2018/5257285. eCollection 2018. |
| 21172605 | Background | Tabares L, Betz B. Multiple functions of the vesicular proton pump in nerve terminals. Neuron. 2010 Dec 22;68(6):1020-2. doi: 10.1016/j.neuron.2010.12.012. |
| 28590010 | Background | Goldstein FC, Steenland K, Zhao L, Wharton W, Levey AI, Hajjar I. Proton Pump Inhibitors and Risk of Mild Cognitive Impairment and Dementia. J Am Geriatr Soc. 2017 Sep;65(9):1969-1974. doi: 10.1111/jgs.14956. Epub 2017 Jun 7. |
| 24165939 | Background | Poea-Guyon S, Ammar MR, Erard M, Amar M, Moreau AW, Fossier P, Gleize V, Vitale N, Morel N. The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery. J Cell Biol. 2013 Oct 28;203(2):283-98. doi: 10.1083/jcb.201303104. |
| 24165933 | Background | Wang D, Hiesinger PR. The vesicular ATPase: a missing link between acidification and exocytosis. J Cell Biol. 2013 Oct 28;203(2):171-3. doi: 10.1083/jcb.201309130. |
| 32428379 | Background | Glebov OO. Understanding SARS-CoV-2 endocytosis for COVID-19 drug repurposing. FEBS J. 2020 Sep;287(17):3664-3671. doi: 10.1111/febs.15369. Epub 2020 Jun 2. |
| 32696234 | Background | Ragia G, Manolopoulos VG. Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies. Eur J Clin Pharmacol. 2020 Dec;76(12):1623-1630. doi: 10.1007/s00228-020-02963-4. Epub 2020 Jul 21. |
| 32311651 | Background | Cure E, Cumhur Cure M. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be harmful in patients with diabetes during COVID-19 pandemic. Diabetes Metab Syndr. 2020 Jul-Aug;14(4):349-350. doi: 10.1016/j.dsx.2020.04.019. Epub 2020 Apr 15. |
| 22808148 | Background | Duwal S, Schutte C, von Kleist M. Pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against HIV-1 infection. PLoS One. 2012;7(7):e40382. doi: 10.1371/journal.pone.0040382. Epub 2012 Jul 11. |
| 34165323 | Background | Bradley BT, Bryan A, Fink SL, Goecker EA, Roychoudhury P, Huang ML, Zhu H, Chaudhary A, Madarampalli B, Lu JYC, Strand K, Whimbey E, Bryson-Cahn C, Schippers A, Mani NS, Pepper G, Jerome KR, Morishima C, Coombs RW, Wener M, Cohen S, Greninger AL. Anti-SARS-CoV-2 Antibody Levels Measured by the AdviseDx SARS-CoV-2 Assay Are Concordant with Previously Available Serologic Assays but Are Not Fully Predictive of Sterilizing Immunity. J Clin Microbiol. 2021 Aug 18;59(9):e0098921. doi: 10.1128/JCM.00989-21. Epub 2021 Aug 18. |
| 19906932 | Background | Graham RL, Baric RS. Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission. J Virol. 2010 Apr;84(7):3134-46. doi: 10.1128/JVI.01394-09. Epub 2009 Nov 11. |
| 26918138 | Background | Pham AQ, Xu LH, Moe OW. Drug-Induced Metabolic Acidosis. F1000Res. 2015 Dec 16;4:F1000 Faculty Rev-1460. doi: 10.12688/f1000research.7006.1. eCollection 2015. |
| 34242582 | Background | Fischer W, Giorgi EE, Chakraborty S, Nguyen K, Bhattacharya T, Theiler J, Goloboff PA, Yoon H, Abfalterer W, Foley BT, Tegally H, San JE, de Oliveira T; Network for Genomic Surveillance in South Africa (NGS-SA); Gnanakaran S, Korber B. HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens. Cell Host Microbe. 2021 Jul 14;29(7):1093-1110. doi: 10.1016/j.chom.2021.05.012. Epub 2021 Jun 3. |
| Background | Dilip KG. Poison as Discussed by Susruta, The Father of Surgery. Biomedical Science and Clinical Research. 2022; 1(1): 18-20. |
| 36597886 | Background | Yonker LM, Swank Z, Bartsch YC, Burns MD, Kane A, Boribong BP, Davis JP, Loiselle M, Novak T, Senussi Y, Cheng CA, Burgess E, Edlow AG, Chou J, Dionne A, Balaguru D, Lahoud-Rahme M, Arditi M, Julg B, Randolph AG, Alter G, Fasano A, Walt DR. Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis. Circulation. 2023 Mar 14;147(11):867-876. doi: 10.1161/CIRCULATIONAHA.122.061025. Epub 2023 Jan 4. |
| Background | Yang IP. Public health equity in information asymmetry - phenomenological studies upon SARS-CoV-2 super- virus mutation. International Physical Medicine & Rehabilitation Journal. 2023; 8(1): 14-18. |
| Proton Pump Inhibitors | View source |
| SARS CoV 2 Spike Antibody, IgG | View source |
| Angiotensin Converting Enzyme Inhibitors (ACEI) | View source |
| Low basophil count in the blood | View source |
| Normal basophil count in the blood | View source |
The local hospital and medicare information are deidentified for their protection. |
| Reset | Apr 3, 2023 |
| Release | Apr 9, 2023 |
| Reset | May 8, 2023 |
| Release | May 14, 2023 |
| Reset | Jun 13, 2023 |
| Release | Jun 15, 2023 |
| Reset | Jul 14, 2023 |
| Release | Jul 17, 2023 |
| Reset | Aug 16, 2023 |
| Release | Sep 24, 2023 |
| Reset | Oct 24, 2023 |
| Release | Nov 9, 2023 |
| Reset | Dec 8, 2023 |
| Release | Dec 9, 2023 |
| Reset | Jun 28, 2024 |
| Release | Jul 6, 2024 |
| Reset | Oct 31, 2024 |
| Release | Nov 7, 2024 |
| Reset | Jan 2, 2025 |
| Release | Jan 17, 2025 |
| Reset | Feb 12, 2025 |
| Release | Jul 4, 2025 |
| Reset | Jul 23, 2025 |
| Release | Jul 25, 2025 |
| Reset | Aug 12, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Feb 2, 2023 | Mar 3, 2023 | |||
| Mar 5, 2023 | Apr 3, 2023 | |||
| Apr 9, 2023 | May 8, 2023 | |||
| May 14, 2023 | Jun 13, 2023 | |||
| Jun 15, 2023 | Jul 14, 2023 | |||
| Jul 17, 2023 | Aug 16, 2023 | |||
| Sep 24, 2023 | Oct 24, 2023 | |||
| Nov 9, 2023 | Dec 8, 2023 | |||
| Dec 9, 2023 | Jun 28, 2024 | |||
| Jul 6, 2024 | Oct 31, 2024 | |||
| Nov 7, 2024 | Jan 2, 2025 | |||
| Jan 17, 2025 | Feb 12, 2025 | |||
| Jul 4, 2025 | Jul 23, 2025 | |||
| Jul 25, 2025 | Aug 12, 2025 |
| ID | Term |
|---|---|
| D045169 | Severe Acute Respiratory Syndrome |
| D014777 | Virus Diseases |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D009543 | Nifedipine |
| C476927 | low mobility group protein 160, rat |
| D004656 | Enalapril |
| D064747 | Lansoprazole |
| D008790 | Metoprolol |
| C024989 | coenzyme Q10 |
| D024502 | alpha-Tocopherol |
| D004281 | Docosahexaenoic Acids |
| D000068736 | Duloxetine Hydrochloride |
| D002214 | Capsules |
| D013482 | Superoxide Dismutase |
| ID | Term |
|---|---|
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D004151 | Dipeptides |
| D009842 | Oligopeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D053799 | 2-Pyridinylmethylsulfinylbenzimidazoles |
| D013454 | Sulfoxides |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D001562 | Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D020005 | Propanols |
| D000588 | Amines |
| D024505 | Tocopherols |
| D014810 | Vitamin E |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D015525 | Fatty Acids, Omega-3 |
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |
| D013876 | Thiophenes |
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |
| D010088 | Oxidoreductases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
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