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The aim of this study is to investigate the effects of Xanthohumol on resting energy expenditure and substrate oxidation in healthy women. It is assumed that resting energy expenditure and fatty acid oxidation is higher after Xanthohumol ingestion.
In a crossover design, 16 healthy young women ingest 172 mg micellar solubilized Xanthohumol or placebo in a randomized fashion. During an observational period of 3 hours, the acute effects of Xanthohumol on the resting energy expenditure and substrate oxidation is determined by respiratory gas analysis. An additional 30-minute determination of the resting energy expenditure and substrate oxidation is executed 24 hours after Xanthohumol ingestion. The wash-out period will be 28 days.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Xanthohumol | Experimental | single dose of 172 mg of micellar solubilized Xanthohumol |
|
| Placebo | Placebo Comparator | Polysorbat 80 (E433) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| micellar solubilized Xanthohumol | Dietary Supplement | single administration of 4 soft gelatine capsules each containing 43 mg micellar solubilized Xanthohumol |
|
| Measure | Description | Time Frame |
|---|---|---|
| Acute Effect on Resting Energy Expenditure | calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24 hours | assessed uninterrupted for 3 hours post dose |
| Prolonged Effect on Resting Energy Expenditure | calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24hours | assessed uninterrupted for 30 minutes 24 h post dose |
| Acute Effect on Substrate Oxidation | assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent | assessed uninterrupted for 3 hours post dose |
| Prolonged Effect on Substrate Oxidation | assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent | assessed uninterrupted for 30 minutes 24 h post dose |
| Measure | Description | Time Frame |
|---|---|---|
| Acute Effect on Blood pressure | given in millimeter mercury | 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose |
| Prolonged Effect on Blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sarah Egert, Prof PhD | University of Bonn | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Bonn | Bonn | 53115 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41723719 | Derived | Brehmer-Henkel S, Diekmann C, Eickeler M, Maris R, Kopp C, Coenen M, Nemeth R, Stoffel-Wagner B, Sus N, Frank J, Egert S. The Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data. Mol Nutr Food Res. 2026 Feb;70(4):e70413. doi: 10.1002/mnfr.70413. |
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| Placebo | Dietary Supplement | single administration of 4 soft gelatine capsules containing only micelles |
|
given in millimeter mercury
| 24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose |
| Acute Effect on Pulse | given in beats per minute | 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose |
| Prolonged Effect on Pulse | given in beats per minute | 24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose |