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Melasma relapse is almost common after discontinuation of conventional treatment. Recent studies have suggested that photoaging dermis is main pathomechanism of melasma emphasizing stromal targeting therapy. Therefore, we investigated maintenance effect of microneedle radiofrequency (RF) for melasma treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional therapy with RF microneedle | Experimental | Half face Oral tranexamic acid combined with triple combination cream with RF microneedle |
|
| Conventional therapy | Active Comparator | Half face Oral tranexamic acid combined with triple combination cream |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RF Microneedle | Device | Pulsed-type RF device in bipolar mode with 25 non-insulated microneedles every 2 weeks for 6 month |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of modified melasma area severity index score | Change of modified melasma area severity index score | Every 1 month up to 8 months |
| Change of lightness value | Change of lightness value by a chromometer | Every 1 month up to 8 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ajou University Hospital | Suwon | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38200171 | Derived | Han HJ, Kim JC, Park YJ, Kang HY. Targeting the dermis for melasma maintenance treatment. Sci Rep. 2024 Jan 10;14(1):949. doi: 10.1038/s41598-023-51133-w. |
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| ID | Term |
|---|---|
| D010859 | Pigmentation Disorders |
| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077442 | Lidocaine, Prilocaine Drug Combination |
| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 |
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split lesion study
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| Combination cream | Drug | 5% hydroquinone, 0.003% tretinoin, and 1% hydrocortisone twice daily for 2 months |
|
| Organic Chemicals |
| D011318 | Prilocaine |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D004338 | Drug Combinations |
| D004364 | Pharmaceutical Preparations |