Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases

Music Intervention and Transcranial Electrical Stimulation for Treating Neurological Diseases

The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are:

• to evaluate the residual neuroplastic processes in DOC state related to music exposure
• to determine the putative modulation of the aforementioned processes and the clinical outcome of DOC patients by non-pharmacological strategies, i.e., electric (tDCS) and music stimulation
• to evaluate the impact of this intervention on caregiver's burden and psychological distress.

Participants will be randomly assigned to one of three different music-listening intervention groups. Primary outcomes will be clinical, that is based on the neurologist's observations of clinical improvement, and neurophysiological, collected pre-intervention, post-intervention and post-placebo.

Inclusion Criteria:

• Age > 18 years
• Post-stroke aphasia
• Post-stroke neglect
• Patients with disorders of consciusness (DOC)

Exclusion Criteria:

• No auditory injury
• no hystory of neurological disease
• No hystory of psychiatric disease
• Previous stroke
• use of alcohol and drugs
• premorbid dementia