Due to some problems in instrumentation acquisition the project has been currently suspended.

The hypothesis under the study is that there could be a link between a dysfunction in peripheral microcirculation, sublingual microcirculation or cardiovascular control and the development of post cardiac surgery major morbidities (stroke, acute kidney injury, prolonged intubation, mediastinitis, surgical reopening, death).

The state of sublingual microcirculation, of peripheral microcirculation and cardiovascular control will be assessed in 100 patients undergoing cardiac surgery during general anesthesia before the intervention and at the end of the intervention at the arrival in post-surgery ICU by means of signal processing techniques.

The extracted markers will be used to assess a statistical prediction model of major morbidities.

Inclusion Criteria:

• age >18 yrs
• indication for a cardiac surgery intervention
• spontaneous sinus rhythm
• informed consent

Exclusion Criteria:

• know autonomic nervous systems pathologies or dysfunctions
• pregnancy

100 consecutive patients scheduled for major cardiac surgery