A Study of Tirzepatide (LY3298176) in Adults With Type 2 Diabetes Switching From a GLP-1 RA (SURPASS-SWITCH-2)

An Open-Label, Single-Arm, Phase 4 Study to Assess Glycemic Control When Adults With Type 2 Diabetes Switch From a GLP-1 RA to Tirzepatide (SURPASS-SWITCH-2)

The main purpose of this study is to investigate the effects of switching from glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy to tirzepatide glucose-dependent insulinotropic polypeptide (GIP) GLP-1 RA agonist in participants with type 2 diabetes (T2D).

Inclusion Criteria:

• Have Type 2 diabetes (T2D)
• Have an HbA1c c ≥6.5% (≥48 mmol/mol) to ≤9.0% (≤75 mmol/mol)
• Have a body mass index (BMI) ≥25 kilogram per square meter (kg/m²) at screening
• Have been on a stable treatment dose of 1 of the listed GLP-1 RAs for ≥3 months
• No treatment with oral antidiabetic medicine (OAM) or on stable doses (for at least 3 months before screening) of up to 3 OAM. The OAM may include metformin, sodium-glucose linked transporter-2 inhibitor (SGLT-2i), thiazolidinediones, or α-glucosidase inhibitors.

Exclusion Criteria:

• Have Type 1 Diabetes (T1D)

• Have a clinical history of

  • proliferative diabetic retinopathy
  • diabetic maculopathy, or
  • non-proliferative diabetic retinopathy that requires acute treatment

• Are at high risk for cardiovascular disease or have a history of

  • myocardial infarction
  • percutaneous coronary revascularization procedure
  • carotid stenting or surgical revascularization
  • nontraumatic amputation
  • peripheral vascular procedure
  • cerebrovascular accident
  • or hospitalization for congestive heart failure

• Have New York Heart Association (NYHA) Functional Classification Class IV congestive heart failure

• Have a history of ketoacidosis or hyperosmolar state or coma

• Have a history of severe hypoglycemia or hypoglycemia unawareness within the 6 months.