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This prospective study aims to observe the predictive effect of peripheral blood plasma biomarker on the outcome of treatment in children with different types of amblyopia. We also investigated the mechanism of neuromodulation in the visual development of amblyopic children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Strabismic |
| ||
| Anisometropic |
| ||
| Isoametropic |
| ||
| Visual deprivation |
| ||
| Mixed group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| standard amblyopia treatment | Procedure | amblyopia treatment following international guidelines and genetic tests. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma protein predictor screening for visual acuity improvement following amblyopia therapy using Tandem Mass Tags proteomics | Peripheral blood will be collected prior and after treatment. The plasma will be separated and Tandem Mass Tags will be used for proteomics. We will detect the different expression of plasma protein between successfully treated and untreated amblyopia patients to find biomarkers that predict amblyopia treatment success. Amblyopia treatment success is defined as best corrected visual acuity (BCVA) improvement of 3 or more logMAR lines. | 2 years after including into this clinical trial |
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Inclusion Criteria:
Exclusion Criteria:
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amblyopia patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jinrong Li, PhD | Contact | 86-020-87330351 | lijingr3@mail.sysu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Ophthalmic Center | Recruiting | Guangzhou | Guangdong | 510060 | China |
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| ID | Term |
|---|---|
| D000550 | Amblyopia |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014786 | Vision Disorders |
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|
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D005128 | Eye Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |