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Postoperative pain remains a very UNPLEASENTevent, particularly in morbidly obese patients that may be associated with obstructive sleep apnea. Bariatric surgery patients must get safe and efficient analgesia, which is essential given that up to 45 % of patients report substantial pain in the first two days following surgery. The study's purpose was to compare the efficacy and safety of combined tramadol with pethidine versus pethidine alone and to assess their impact on postoperative pethidine requirements after LSG for morbidly obese patients
This multicenter cohort research included patients with morbid obesity who had LSG between January 2021 and December 2022. The patients included in the study were allocated to one of two treatment groups that were not randomized but the patients were categorized according to the time of surgery: Group A received Pethidine alone in the period between January 2021 and December 2021, while Group B got Tramadol with pethidine in the period between January 2022 and December 2022. Doses were based on the patient's actual body weight.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A received Pethidine alone in the period between January 2021 and December 2021, | Active Comparator | received Pethidine alone in the period between January 2021 and December 2021, while |
|
| Group B got Tramadol with pethidine in the period between January 2022 and December 2022. | Active Comparator | Group B got Tramadol with pethidine in the period between January 2022 and December 2022. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pethidine | Drug | Group A received Pethidine alone in the period between January 2021 and December 2021 |
|
| Measure | Description | Time Frame |
|---|---|---|
| VAS of pain | the severity of pain | 48 hours postoperative |
| opioid requirement | the need of pethidine | one month |
| Measure | Description | Time Frame |
|---|---|---|
| hospital stay | hospital stay | one month |
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Inclusion Criteria:
Exclusion Criteria:
16-65
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| Name | Affiliation | Role |
|---|---|---|
| Ayman E Nakeeb | Mansoura University, Gastrointestinal Surgery Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ayman El Nakeeb | Al Mansurah | Outside U.S and Canada | 35111 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31286397 | Result | Zeeni C, Aouad MT, Daou D, Naji S, Jabbour-Khoury S, Alami RS, Safadi BY, Siddik-Sayyid SM. The Effect of Intraoperative Dexmedetomidine Versus Morphine on Postoperative Morphine Requirements After Laparoscopic Bariatric Surgery. Obes Surg. 2019 Dec;29(12):3800-3808. doi: 10.1007/s11695-019-04074-1. | |
| 35422388 | Result |
| Label | URL |
|---|---|
| mansoura university | View source |
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the study protocol will be available for another researcher
available for any researcher at any time
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D009767 | Obesity, Morbid |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D008614 | Meperidine |
| D014147 | Tramadol |
| ID | Term |
|---|---|
| D007540 | Isonipecotic Acids |
| D000147 | Acids, Heterocyclic |
| D006571 | Heterocyclic Compounds |
| D010880 | Piperidines |
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Group A received Pethidine alone in the period between January 2021 and December 2021, while Group B got Tramadol with pethidine in the period between January 2022 and December 2022. Doses were based on the patient's actual body weight.
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Group A received Pethidine alone in the period between January 2021 and December 2021, while Group B got Tramadol with pethidine in the period between January 2022 and December 2022. Doses were based on the patient's actual body weight.
|
| Tramadol with pethidine | Drug | Group B got Tramadol with pethidine in the period between January 2022 and December 2022 |
|
|
| Zhang Y, Zhou Y, Hu T, Tong X, He Y, Li X, Huang L, Fu Q. Dexmedetomidine reduces postoperative pain and speeds recovery after bariatric surgery: a meta-analysis of randomized controlled trials. Surg Obes Relat Dis. 2022 Jun;18(6):846-853. doi: 10.1016/j.soard.2022.03.002. Epub 2022 Mar 9. |
| 34323436 | Result | Tian C, Lee Y, Oparin Y, Hong D, Shanthanna H. Benefits of Transversus Abdominis Plane Block on Postoperative Analgesia after Bariatric Surgery: A Systematic Review and Meta-Analysis. Pain Physician. 2021 Aug;24(5):345-358. |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D006573 |
| Heterocyclic Compounds, 1-Ring |
| D003511 | Cyclohexanols |
| D000441 | Hexanols |
| D005233 | Fatty Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D004123 | Dimethylamines |
| D008744 | Methylamines |
| D000588 | Amines |
| D008055 | Lipids |