Physical and Psychological Changes in CRPS Patients Undergoing Multimodal Rehabilitation

Physical and Psychological Changes in Complex Regional Pain Syndrome (CRPS) Patients Undergoing Multimodal Rehabilitation

The goal of this clinical trial is to learn about cognitive changes during rehabilitation in CRPS patients. The main questions it aims to answer are:

• What are the cognitive changes in CRPS?
• Do cognitive functions change during multimodal rehabilitation in CRPS?
• What is the effect of multimodal rehabilitation on pain, functioning, mood, active range of motion, cognitive functions.

Participants will undergo a 4-week program of multimodal rehabilitation of physical therapy, education and Graded Motor Imagery. Assessment will be made at baseline and after 4 weeks.

Researchers will compare the interventional arm with healthy control to see if the observed psychological results are exclusive to CRPS group.

There is no expanded access scheduled for this study.

Inclusion Criteria:

• Clinical diagnosis of CRPS (or equivalent);
• MMSE >24 points;
• Has signed an informed consent to the study.

Exclusion Criteria:

• MMSE ≤24 points;
• Inability to perform scheduled tasks (multimodal rehabilitation program).