Effects of Music Therapy in Controlling Symptoms in Patients With AML and Undergoing HSCT

Effects of Music Therapy in Controlling Symptoms in Patients With Acute Myeloblastic Leukemia and Undergoing Hematopoietic Stem Cell Transplantation: a Randomized Controlled Clinical Trial

The goal of this clinical trial is to test passive music therapy in patients receiving induction chemotherapy for an acute myeloblastic leukemia or undergoing an hematopoietic stem cell transplantation. The main questions it aims to answer are:

- Can music therapy control physical and psychological symptoms and improve the mood and quality of life of these patients?

Participants will be randomly assigned to the control and experimental group. Patients included in both groups will complete weekly mood and quality of life questionnaires. Those included in the experimental group will also complete daily symptom burden questionnaires before and after listening to a music therapy session.

Researchers will confirm if the experimental group improves their symptoms after the music therapy session and will compare both groups to see if there are differences in mood and quality of life.

Inclusion Criteria:

• ≥ 18 years old.
• Patients receiving induction chemotherapy for a newly diagnosed acute myeloblastic leukemia (except for acute promyelocytic leukemia).
• Patients undergoing autologous or allogeneic stem cell transplantation.
• Being able to understand and read Spanish properly.
• Basic computer skills.

Exclusion Criteria:

• Moderate-severe hearing impairment (unilateral or bilateral).
• Past history of psychiatric disorders.
• Performance status: ECOG ≥ 3.