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"Several case reports have described the use of rocuronium and sugammadex in patients with myasthenia gravis (MG). However, reports regarding the effects of sugammadex compared with that of acetylcholinesterase inhibitors (AChEIs) on perioperative outcomes of video-assisted thoracoscopic surgery (VATS)-thymectomy in patients with MG are still lacking. Thus, the investigators will investigate the effects of sugammadex compared to AChEIs on the postoperative recovery in patients with MG who underwent VATS-thymectomy.
This retrospective study include patients with MG, aged> 18 years who received sugammadex or pyridostigmine-glycopyrrolate or neostigmine-glycopyrrolate after VATS-thymectomy between November 2007 and December 2020. Inverse Probability of Treatment Weighting (IPTW) adjustment will be performed to balance the baseline characteristics between the two groups. The primary outcome is the length of postoperative hospital stay, and the secondary outcomes are the incidence of postoperative mortality and postoperative complications, as well as postoperative extubation and reintubation rates in the operating room after VATS-thymectomy; the outcomes are compared between the two groups. "
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sugammadex group | patients who administered sugammadex | ||
| AChEI group | patients who administered pyridostigmine-glycopyrrolate or neostigmine-glycopyrrolate |
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| Measure | Description | Time Frame |
|---|---|---|
| hospital stay | length of postoperative hospital stay (day) | up to 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of postoperative mortality | up to 1 year | |
| postoperative complication incidence | up to 1 year | |
| postoperative extubation rate in the OR |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with myasthenia gravis who underwent video-assisted thoracoscopic thymectomy
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| Name | Affiliation | Role |
|---|---|---|
| Na Young Kim | Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yonsei University Health System, Severance Hospital | Seoul | South Korea |
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3years
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| ID | Term |
|---|---|
| D009157 | Myasthenia Gravis |
| ID | Term |
|---|---|
| D020361 | Paraneoplastic Syndromes, Nervous System |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| up to 1 year |
| postoperative reintubation rate in the OR | up to 1 year |
| D010257 | Paraneoplastic Syndromes |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D019636 | Neurodegenerative Diseases |
| D020511 | Neuromuscular Junction Diseases |
| D009468 | Neuromuscular Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |