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Preterm birth is associated with maternal increased risk of cardiovascular disease later in life. In an observational case- control study, investigators want to evaluate whether women with preterm birth have increased levels of biomarkers for cardiovascular disease, to reveal potential pathophysiological mechanisms in common.
Women with spontaneous preterm birth in first pregnancy and a group of matched controls with spontaneous birth in normal time where invited to participate in the study. Participants were identified from the Biobank of Pregnant Women in Uppsala. Levels of cardiovascular biomarkers will be analyzed in plasma samples from the pregnancy and at a follow-up visit where investigators also collect information about other cardiovascular risk factors and lipid status.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preterm birth | Women with spontaneous preterm birth in first pregnancy |
| |
| Controls | Matched controls with spontaneous delivery in normal time in first pregnancy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | No intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Levels of Factor XII in plasma in women with preterm birth in compared to a control group with delivery in normal time. | Levels of Factor XII in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. | spring 2023 |
| Levels of complement C5 in women with preterm birth in compared to a control group with delivery in normal time. | Levels of complement C5 in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. | spring 2023 |
| Levels of apolipoprotein M in women with preterm birth in compared to a control group with delivery in normal time. | Levels of apolipoprotein M in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. | spring 2023 |
| Levels of fibrinogen in women with preterm birth in compared to a control group with delivery in normal time. | Levels of fibrinogen in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. | spring 2023 |
| Levels of plasma kallikrein in women with preterm birth in compared to a control group with delivery in normal time. | Levels of plasma kallikrein in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. | spring 2023 |
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Inclusion Criteria:
Exclusion Criteria:
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Women were identified in the Uppsala Biobank of pregnant women at their first pregnancy. Investigators invited women identified as cases or controls to participate by one blood sample and a visit collecting information about cardiovascular risk factors.
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| Name | Affiliation | Role |
|---|---|---|
| Christina Christersson | Uppsala University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medical Sciences, Uppsala University | Uppsala | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38379394 | Derived | Cederlof ET, Lager S, Larsson A, Sundstrom Poromaa I, Lindahl B, Wikstrom AK, Christersson C. Biomarkers associated with cardiovascular disease in women with spontaneous preterm birth: A case-control study. Acta Obstet Gynecol Scand. 2024 May;103(5):970-979. doi: 10.1111/aogs.14813. Epub 2024 Feb 20. |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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Plasma collected at two time points, in pregnancy and at follow-up.
| Levels of vitamin D binding protein in women with preterm birth in compared to a control group with delivery in normal time. | Levels of vitamin D binding protein in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. | spring 2023 |
| Levels of cadherin -5 in women with preterm birth in compared to a control group with delivery in normal time. | Levels of cadherin -5 in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. | spring 2023 |
| Levels of growth/differentiation Factor-15 (GDF-15) in women with preterm birth in compared to a control group with delivery in normal time. preterm birth compared to a control group with delivery in normal time. | Levels of growth/differentiation Factor-15 (GDF-15) in plasma will be analyzed at two times, both in the actual pregnancy and at a follow-up visit where information about cardiovascular risk factors and lipid status is collected. | spring 2023 |
| D000091642 | Urogenital Diseases |