An association between periodontitis and endothelial dysfunction has been reported, suggesting that periodontitis presents an inflammatory burden to the cardiovascular system, that might lead to AVD. The study aims aim to assess whether non-surgical periodontal therapy enhances endothelial function in periodontitis patients using a non-invasive diagnostic device to assess endothelial function through PWA and the assessment of levels of salivary Endothelin-1, in a population of people in the UAE.

Inclusion Criteria:

• Group 1: periodontally healthy subjects.
• Group 2: patients with periodontitis stage III or IV and grades A,B or C.

Exclusion Criteria:

• Medical conditions: Diabetes,pregnancy,obesity,renal disease,patients with cardiovascular diseases including hypertension,recent myocardial infarction or unstable angina (within 3 months),congestive heart failure,valvular heart disease
• Heavy smokers(>10 cigarettes per day),
• Regular administration of drugs resulting in gingival hyperplasia,root planning in the past 6 months
• Regular administration of drugs resulting in gingival hyperplasia (such as cyclosporine and phenytoin)
• Recent antibiotic use (in the past 3 months)
• Non-surgical periodontal therapy in the past 6 monthsp

Patients recruited from the pool of patients consulting at Postgraduate teachingb clinics of the University Dental Hospital Sharjah