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comparison between standard cross-linking protocol and accelerated and transepithelial cross-linking
comparison between standard cross-linking protocol and accelerated and transepithelial cross-linking for treatment of documented pediatric keratoconus progression. The study patients are divided into 3 groups. Group A patient treated with standard cross-linking. Group B patients treated with accelerated cross-linking. Group C patients treated with transepithelial cross-linking.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard CXL | Other | Patients treated according to Dresden Protocol with epithelium-off CXL. |
|
| Accelerated CXL | Experimental | Patients treated according to accelerated Protocol with epithelium-off CXL. |
|
| Transepithelial CXL | Experimental | Patients treated according to transepithelial Protocol with epithelium-on CXL. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard CXL | Procedure | Epithelium-off CXL performed by removal of corneal epithelium, instillation of riboflavin onto the cornea followed by UVA corneal irradiation for 30 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Uncorrected distance visual acuity | measured in logarithm of minimal angle of resolution (logMAR) | 36 months |
| Corrected distance visual acuity | measured in logarithm of minimal angle of resolution (logMAR) | 36 months |
| Sphere | measured in diopters (D) | 36 months |
| Cylinder | measured in diopters (D) | 36 months |
| Keratometry (Kmax) | measured in diopters (D) | 36 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mohammed Iqbal, MD, PhD | Sohag University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of medicine | Sohag | 82425 | Egypt |
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| ID | Term |
|---|---|
| D000094504 | Corneal Cross-Linking |
| ID | Term |
|---|---|
| D010778 | Photochemotherapy |
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
| D004358 | Drug Therapy |
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| Accelerated CXL | Procedure | Epithelium-off CXL performed by removal of corneal epithelium, instillation of riboflavin onto the cornea followed by UVA corneal irradiation for 5 minutes. |
|
| Transepithelial CXL | Procedure | Epithelium-on CXL performed by instillation of riboflavin onto the cornea followed by UVA corneal irradiation for 5 minutes. |
|
| D010789 |
| Phototherapy |