EUS-PPG vs HVPG in Portal Hypertension

EUS-portal Pressure Gradient (EUS-PPG). Prospective Study Compared With Hepatic Venous Pressure Gradient (HVPG)

The objective of this study is to evaluate the correlation of the calculated portal pressure gradient (PPG) obtained by direct portal and hepatic pressure measurements with a conventional 22 G needle guided by EUS and indirect portal vein pressure measurements using the interventional radiology based hepatic venous pressure gradient (HVPG) procedure.

Inclusion Criteria:

• Age above 18 years
• Undergoing evaluation for chronic liver disease or portal hypertension
• Signed informed consent

Exclusion Criteria:

• Uncorrectable coagulopathy (INR above 1.5)
• Uncorrectable thrombocytopenia (Platelets under 50,000)
• Anticoagulation or antiplatelet therapy that cannot be discontinued
• Biliary obstruction
• Grade II ascites or more
• Intrahepatic portal vein thrombosis
• Pregnancy