Assessment of Intubation conditions following administration of neuromuscular blocking agents; BX1000 (investigational) or rocuronium (active control).

Intubation conditions will be assessed in anesthetized subjects undergoing an elective surgical procedure utilizing general anesthesia. Following administration of IV anesthesia, subjects will have electromyography (EMG) neuromuscular monitoring device applied prior to administration of neuromuscular blocking agent (NMBA). NMBA will be administered and assessment of intubation conditions will begin 60 seconds after administration according to the methods defined in Viby-Mogensen 1996; assessment will be repeated at 90 and 120 seconds after administration when intubation has not already been completed.

After intubation is completed, subjects will progress to have their elective surgery completed and will be maintained under general anesthesia until neuromuscular function is recovered. Once recovered from anesthesia and extubation, subjects will be monitored in a recovery area until they are suitable to be discharged to the inpatient floor, after which time they may be discharged at the clinical discretion of the investigator.

Inclusion Criteria:

• Providing informed consent
• Undergoing elective surgery utilizing IV general anesthesia
• Normal airway assessment

Exclusion Criteria:

• Unstable disease or emergency surgical conditions
• Known hypersensitivity to rocuronium, other NMB or study medications
• History of anaphylaxis
• History of neuromuscular junction disease
• Personal or family history of malignant hyperthermia or pseudocholinesterase deficiency
• Diagnosed or suspected sleep apnea
• History of prior anesthetic complications

Double-blind, active controlled