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| Name | Class |
|---|---|
| The First Affiliated Hospital of Dalian Medical University | OTHER |
| The Second Hospital of Hebei Medical University | OTHER |
| Yantaishan Hospital | UNKNOWN |
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Narrow band imaging(NBI) could improve the detection of colorectal lesions, previous investigations demonstrated its potential in detecting not only colorectal adenoma but non-adenomatous polyps, including sessile serrated lesions. But no randomized controlled trials with NBI versus white light imaging(WLI) have been conducted to give a definitive conclusion with statistically significant differences. Therefore, we performed a multicenter, prospective, back to back, randomized controlled trial to compare sessile serrated lesions detection and miss rate of withdraw by NBI and WLI in colonoscopy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| WLI Then NBI Withdrawal Group | Experimental | After successful intubation of the cecum, carefully inspect the whole colorectal mucosa by white light imaging(WLI) during the first colonoscopy withdraw. Then reinsert to the cecum and withdraw with narrow band imaging(NBI). Stop watch will be utilized to remind endoscopists. |
|
| NBI Then WLI Withdrawal Group | Active Comparator | After successful intubation of the cecum, carefully inspect the whole colorectal mucosa by narrow band imaging(NBI) during the first colonoscopy withdraw. Then reinsert to the cecum and withdraw with white light imaging(WLI). Stop watch will be utilized to remind endoscopists. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| WLI Then NBI Withdrawal | Procedure | Patients in WLI then NBI withdrawal group will first be carefully inspected by white light imaging(WLI), each polyp found should be removed. According to the ESGE guideline of colorectal polypectomy, the lesions which size between 4-9mm should by removed by cold snare. Cold biopsy forceps could be utilized considering the difficulty in resection of flat and diminutive polyps(size ≤ 3mm). Then change to narrow band imaging(NBI) for the second withdraw to detect the lesions which found in second time but not the first. |
| Measure | Description | Time Frame |
|---|---|---|
| sessile serrated lesions miss rate(SSLMR) | Sessile serrated lesions(SSLs) detected in the second-pass examination were defined as missed SSLs; the sessile serrated lesions miss rate(SSLMR) was defined as follows: number of SSLs detected in the second-pass examination/total number of SSLs detected in both two pass. | 60 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| sessile serrated lesions detection rate(SSLDR) | Sessile serrated lesions detection rate(SSLDR) is the number of patients with at least one sessile serrated lesion detected by narrow band imaging or white light imaging, divided by the total number of patients. | 60 minutes |
| adenoma miss rate(AMR) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhaoshen Li, MD | Contact | 86-021-31161365 | li.zhaoshen@hotmail.com | |
| Yu Bai, MD | Contact | 86-021-31161335 | baiyu1998@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Zhaoshen Li, MD | Changhai Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Changhai Hospital, Second Military Medical University | Recruiting | Shanghai | Shanghai Municipality | 200433 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36219172 | Background | Zhao S, Song Y, Wang S, Wang R, Feng Z, Gong A, Yang X, Pan P, Yao D, Zhang J, Zhu Y, Li T, Bi J, Ren X, Tang X, Li Q, Yu D, Zheng J, Song B, Wang P, Chen W, Shang G, Xu Y, Xu P, Lai Y, Xu H, Yang X, Sheng J, Tao Y, Li X, Zhu Y, Zhang X, Shen H, Ma Y, Wang F, Wu L, Wang X, Li Z, Bai Y. Reduced Adenoma Miss Rate With 9-Minute vs 6-Minute Withdrawal Times for Screening Colonoscopy: A Multicenter Randomized Tandem Trial. Am J Gastroenterol. 2023 May 1;118(5):802-811. doi: 10.14309/ajg.0000000000002055. Epub 2022 Oct 11. | |
| 35390509 |
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| The Second Affiliated Hospital of Guangzhou University of Chinese Medicine |
| UNKNOWN |
| 900th Hospital of PLA Joint Logistic Support Force | OTHER |
| Heilongjiang Provicial Hospital | OTHER |
| Ankang Central Hospital | OTHER |
| Nongken Jiansanjiang People Hospital of Heilongjiang Province | UNKNOWN |
| Huadong Hospital | OTHER |
| The Second Affiliated Hospital of Baotou Medical College | OTHER |
| Qilu Hospital of Shandong University | OTHER |
| Shandong First Medical University | OTHER |
| Air Force Military Medical University, China | OTHER |
| Tengzhou Central People's Hospital | OTHER_GOV |
| Chongqing General Hospital | OTHER |
| Haikou People's Hospital | OTHER |
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| NBI Then WLI Withdrawal | Procedure | Patients in NBI then WLI withdrawal group will first be carefully inspected by narrow band imaging(NBI), each polyp found should be removed. According to the ESGE guideline of colorectal polypectomy, the lesions which size between 4-9mm should by removed by cold snare. Cold biopsy forceps could be utilized considering the difficulty in resection of flat and diminutive polyps(size ≤ 3mm). Then change to white light imaging(WLI) for the second withdraw to detect the lesions which found in second time but not the first. |
|
Adenomas detected in the second-pass examination were defined as missed adenomas; the adenoma miss rate(AMR) was defined as follows: number of adenomas detected in the second-pass examination/total number of adenomas detected in the two pass. |
| 60 minutes |
| adenoma detection rate(ADR) | Adenoma detection rate(ADR) is the number of patients with at least one adenoma detected by narrow band imaging or white light imaging, divided by the total number of patients. | 60 minutes |
| Background |
| Li J, Zhang D, Wei Y, Chen K, Wu R, Peng K, Hou X, Li L, Huang C, Wang Y, Xun L, Xu H, Wang J, Chen Z, Shen M, Liu F. Colorectal Sessile Serrated Lesion Detection Using Linked Color Imaging: A Multicenter, Parallel Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2023 Feb;21(2):328-336.e2. doi: 10.1016/j.cgh.2022.03.033. Epub 2022 Apr 4. |
| 25952085 | Background | Rex DK, Clodfelter R, Rahmani F, Fatima H, James-Stevenson TN, Tang JC, Kim HN, McHenry L, Kahi CJ, Rogers NA, Helper DJ, Sagi SV, Kessler WR, Wo JM, Fischer M, Kwo PY. Narrow-band imaging versus white light for the detection of proximal colon serrated lesions: a randomized, controlled trial. Gastrointest Endosc. 2016 Jan;83(1):166-71. doi: 10.1016/j.gie.2015.03.1915. Epub 2015 May 5. |
| 41638419 | Derived | Wei J, Zhang S, Fang Q, Sui X, Tang X, Shi L, Zhao Y, Hu H, Huang Z, Huang X, Zhang H, Wang S, Li X, Wang C, Guo Y, Xu B, Wu W, Su Y, Chen L, Wei R, Li P, Shi L, Tang B, Qiao X, Xu M, Zhang J, Ji R, Ji D, Gong A, Li B, Ren J, Jiang Z, Xu H, Li M, Wang W, Yu J, Feng Z, Zhang J, Yao D, Li Z, Zhao S, Bai Y. Impact of Narrow-Band Imaging on Sessile Serrated Lesion Miss Rate: A Multicenter Randomized Tandem Colonoscopy Trial. Clin Gastroenterol Hepatol. 2026 Jul;24(7):1823-1835. doi: 10.1016/j.cgh.2026.01.027. Epub 2026 Feb 3. |