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The present study is a retrospective and prospective current care cohort that will allow us to evaluate the relationship between epicardial fat volume and increased arterial stiffness in a person living with diabetes.
Epicardial adipose tissue is considered as the cardiac visceral fat and is associated with increased cardiovascular risk, for example in diabetes. Thus, the mechanisms involved seem to be related to myocardial lipotoxicity; atherosclerosis in connection with inflammation and secretion of proinflammatory factors such as cytokines but also insulin resistance.
In this context, the investigators hypothesize that epicardiac adipose tissue volume will be higher in patients with increased arterial stiffness than in those without. In this study, the investigators will then try to verify the existence of a relationship between pericardial adipose tissue volume and increased arterial stiffness in people living with diabetes.
To do this, the investigators will analyze the results of measurements of pericardial fat volume, coronary calcium score, and pulse wave velocity in diabetic patients.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CT scan | Procedure | coronary calcium score measurement by CT scan |
| Measure | Description | Time Frame |
|---|---|---|
| Epicardial fat volume | Epicardial fat volume will be determined using cardiac CT scan without contrast injection. | the inclusion visit |
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Inclusion Criteria:
Patients will be eligible for participation in the study if:
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Type 1 or 2 diabetic patients who perform coronary calcium score measurement by CT scan and pulse wave velocity assessment as part of their routine care practice.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emmanuel COSSON, Pr | Contact | 01 48 95 51 54 | emmanuel.cosson@aphp.fr | |
| Omar NOUHOU KOUTCHA, Dr | Contact | 07 64 18 07 14 | omarnouhou1@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Emmanuel COSSON, Pr | APHP, Hospital Avicenne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| endocrinologie site, Avicenne hospital | Recruiting | Bobigny | 93000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41094476 | Derived | Koutcha ON, Tatulashvili S, Sritharan N, Boutouyrie P, Rezgani I, Boubaya M, Mariko ML, Allard L, Sal M, Bloch-Queyrat C, Zerguine M, Brillet PY, Fekih ZE, Bruno RM, Bihan H, Cosson E. Epicardial adipose tissue volume and arterial stiffness in people living with diabetes: the METAB-CV-PWV study. Cardiovasc Diabetol. 2025 Oct 15;24(1):400. doi: 10.1186/s12933-025-02933-z. |
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