The current study was designed to check the impact of black raspberry (BR) on obese and mild Alzheimers (AZ) patients infected with Helicobacter pylori (H pylori). Through checking various parameters including anthropometric, antioxidants, and CDR.

The current study was designed to check the impact of black raspberry (BR) on obese and mild Alzheimers (AZ) patients infected with Helicobacter pylori (H pylori).

Preclinical studies (In vitro model) were conducted using 3T3-L1 adipocyte cells to check the anti-adhesion activity of BR.

For the clinical trial, a total of 21 obese mild AZ patients were recruited and separated into 2 groups: Experimental (BR group) and Placebo group.

Experimental group and Placebo group subjects were requested to take either 50 g of BR or 50 g of dextrin respectively for 4 weeks.

Inclusion Criteria:

• BMI ≧ 27, Waist circumference: men ≧ 90cm, women ≧ 80cm,
• Body fat: male ≧ 25%, female ≧ 30%,
• UBT 13C test value> 10‰ (H. pylori (+)),
• CDR (clinical dementia rating) = 0.5

Exclusion Criteria:

• BMI< 27
• Severe chronic diseases (liver disease, cardiovascular disease, kidney disease)
• Alcohol abuse
• Smoking habit
• Taking berry-related supplementation or any known allergies related to berries.
• Subjects with prior history of H. pylori infection were treated with triple therapy.