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| Name | Class |
|---|---|
| Psychiatric University Hospital, Zurich | OTHER |
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Intrusive memories represent a debilitating core feature of PTSD, one of the most prevalent psychiatric disorders following trauma. Exposure therapy is amongst the most successful treatments of PTSD that is recommended by most of the current national and international guidelines. The current study aims to test whether sleep as adjunct to written exposure sessions, a type of exposure- based treatment for PTSD, may boost the effectiveness of the therapy.
Intrusive memories represent a debilitating core feature of PTSD, one of the most prevalent psychiatric disorders following trauma. Exposure therapy is amongst the most successful treatments of PTSD that is recommended by most of the current national and international guidelines. However, not all patients benefit equally and only about 50% show sustained response. There is thus room for improvement in terms of (i) better understanding who benefits from this type of therapy and (ii) possible ways of augmenting existing trauma-focused therapies. The current study aims to contribute to these endevours. Specifically, the study aims to test whether sleep as adjunct to written exposure sessions, a type of exposure- based treatment for PTSD, may boost the effectiveness of the therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sleep after exposure | Experimental | Participants take a nap during 90 min following three exposure (WET) sessions. |
|
| Wake after exposure | No Intervention | Participants watch a 90 min documentary following three exposure (WET) sessions. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sleep/Nap | Behavioral | Participants sleep after a maximum of three sessions of exposure therapy. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinician- assessed Posttraumatic stress symptom severity at 1 week | Clinician- assessed PTSD symptom severity (CAPS- 5) | One week post- treatment |
| Self-reported Posttraumatic stress symptom severity at 1 week | Self - reported PTSD symptom severity (PCL-5) | One week post- treatment |
| Clinician- assessed Posttraumatic stress symptom severity at 1 month | Clinician- assessed PTSD symptom severity (CAPS- 5) | One month post- treatment |
| Self-reported Posttraumatic stress symptom severity at 1 month | Self - reported PTSD symptom severity (PCL-5) | One month post- treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Total sleep time | Total sleep time according to EEG | Immediately after written exposure therapy |
| Time spent in N1 sleep | N1 time according to EEG |
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Inclusion Criteria:
Exclusion Criteria:
Specific exclusion criteria for the fMRI:
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| Name | Affiliation | Role |
|---|---|---|
| Birgit Kleim, PhD | Zurich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Psychiatric University Hospital | Zurich | Canton of Zurich | 8032 | Switzerland |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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Randomised controlled trial
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Psychotherapists and outcome assessors are blind to participants' group membership (i.e., sleep versus wake after exposure therapy)
| Immediately after written exposure therapy |
| Time spent in N2 sleep | N2 time according to EEG | Immediately after written exposure therapy |
| Time spent in N3 sleep | N3 time according to EEG | Immediately after written exposure therapy |