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Very little is currently known about the pathophysiology of pruritus sine materia according to the etiology. The creation of this cohort should make it possible to improve our clinical and biological knowledge according to the etiology, by collecting blood, skin, feces, and clinical data.
At inclusion, 52.5 ml of blood will be collected, then an additional skin biopsy and a skin swab. Five questionnaires will be filled in by the patient.
At 6 months, then every years for 5 years, the same 5 questionnaires will be collected as well as the clinical data. However, no more biological samples will be collected.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patient library | Patient with pruritus sine materia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood samples | Other | At inclusion :
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical description of the pruritus | Chronology | 5 years |
| Clinical description of the pruritus | Intensity | 5 years |
| Clinical description of the pruritus | Location | 5 years |
| Clinical description of the pruritus | Aggravating and ameliorating factors | 5 years |
| Clinical description of the pruritus | Evolution | 5 years |
| Clinical description of the pruritus | Scratching | 5 years |
| Clinical description of the pruritus | Chronology, intensity, location, aggravating and ameliorating factors, evolution, scratching | 5 years |
| 5-D itch scale questionnaire | The scores for each of the five domains (duration, degree, direction, disability, ditribution) are calculated separately and then added together to obtain a total 5-D score. The 5-D score can range from 5 (no pruritus) to 25 (most severe pruritus). Scores with a single item (duration, degree, direction) are equal to the value indicated by the answer choice (from 1 to 5). The impact of pruritus (disability) includes four items that assess the impact of itching on daily activities: sleep, leisure activities, social activities, domestic activities, work/study. The score for impact is reached by taking the highest score on any of the four items. For location (distribution), the number of body parts affected is collected (potential sum of 0 to 16) and the sum is classified into 5 scores:
|
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Inclusion Criteria:
Exclusion Criteria:
- Refusal to participate in the study
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Patient with pruritus sine materia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Laurent MISERY | Contact | 02 98 22 33 15 | laurent.misery@chu-brest.fr | |
| Emilie BRENAUT | Contact | emilie.brenaut@chu-brest.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de dermatologie, CHRU BREST | Recruiting | Brest | 29200 | France |
All collected data that underlie results in a publication
Data will be available after the publication of result and ending fifteen years following the last visit of the last patient
Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement
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| ID | Term |
|---|---|
| D011537 | Pruritus |
| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D012877 | Skin Manifestations |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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6 mL of blood will be collected at inclusion to extract the dna
| skin swab sample | Other | At inclusion a skin swab sample will be collected |
|
| skin biopsy sample | Other | At inclusion a skin biopsy sample will be collected |
|
| Questionnaires | Other | At inclusion, at 6 months and every year, the patient will respond to 5 questionnaires : Brest questionnaire, 5-D itch scale, Dermatology Life Quality Index, Itchy Quality of Life and Hospital Anxiety and Depression Scale |
|
| 5 years |
| Dermatology Life Quality Index questionnaire (DLQI) | DLQI = Dermatology Life Quality Index is a ten-item questionnaire. The score ranges from 0 to 30. Each question is rated from 0 to 3. The higher the score, the worse the health status. Interpretation of DLQI: DLQI scores 0-1: no effect on patient's life DLQI scores 2-5: small effect on patient's life DLQI scores 6-10: moderate effect on patient's life DLQI scores 11-20: very large effect on patient's life DLQI scores 21-30: extremely large effect on patient's life | 5 years |
| Hospital anxiety and depression questionnaire (HAD) | The HAD scale is an instrument to screen for anxiety and depressive disorders. It consists of 14 items rated from 0 to 3. Seven questions relate to anxiety (total A) and seven others to the depressive dimension (total D), thus making it possible to obtain two scores (maximum score for each score = 21). To screen for anxiety and depressive symptoms, the following interpretation can be proposed for each of the scores (A and D)
| 5 years |
| Brest Questionnaire | The Brest questionnaire is a descriptive tool. No score is calculated. | 5 years |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |