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This study is testing a new brief mindfulness practice for people suffering from long COVID-19 symptoms. People suffering from long COVID are particularly vulnerable to negative emotions, as they must also cope with the long-term uncertainty of physical and psychological stress beyond the acute infection. The goal of the study is to measure the ability of a brief mindfulness practice to promote a sense of well-being in people suffering from long COVID.
This is a pilot randomized waitlist-controlled clinical trial (RCT) testing a new brief self-care intervention for people suffering from post-acute sequelae SARS-CoV-2 infection (PASC). The overarching goal of this study is to establish the feasibility and early efficacy of microdosing mindfulness as a self-care intervention. The purpose of the intervention is to promote a sense of well-being among PASC patients who currently have limited access to other proven self-care modalities.
Our research question is whether our newly developed training can assist PASC patients to self-microdose mindfulness (5-15 seconds activities in everyday life) and improve on perceived metrics of well-being (primary outcome). Our hypothesis is that self-microdosing mindfulness will evoke positive emotions that can improve well-being on patients suffering of PASC-related symptoms beyond 3 months post COVID-19 infection. If effective, an increased frequency of the mindfulness activity will then help buffer negative emotions (e.g., anger, loneliness, etc.) experienced during the pandemic and associated with ongoing stress and/or somatic symptoms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Waitlist control | No Intervention | ||
| Treatment | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Microdosing of mindfulness | Behavioral | The intervention consists of two parts: 1) four structured training sessions offered as online synchronous classes, and 2) self-microdosing of mindfulness activities in everyday life. |
| Measure | Description | Time Frame |
|---|---|---|
| Well-being | 14 items from the Mental Health Continuum Short Form | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Perceived Stress | Perceived Stress Scale | 1, 3 and 12 months |
| Anxiety symptoms | Generalized Anxiety Disorder scale | 1, 3 and 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Javier E Lopez, MD | University of California, Davis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California Davis | Sacramento | California | 95817 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40355653 | Derived | Monroy M, Amster M, Eagle J, Zerwas FK, Keltner D, Lopez JE. Awe reduces depressive symptoms and improves well-being in a randomized-controlled clinical trial. Sci Rep. 2025 May 12;15(1):16453. doi: 10.1038/s41598-025-96555-w. |
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| ID | Term |
|---|---|
| D000094024 | Post-Acute COVID-19 Syndrome |
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
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| Depressive symptoms | Beck Depression Inventory Short Form | 1, 3 and 12 months |
| Physical health | Physical health symptoms - 11 items + 3 items of COVID symptoms | 1, 3 and 12 months |
| Cardiac symptoms | Cardiac symptoms by the Kansas City Cardiomyopathy Questionnaire-12 items (KCCQ-12) | 1, 3 and 12 months |
| Well-being | 14 items from the Mental Health Continuum Short Form | 3 and 12 months |
| D007239 |
| Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D000094025 | Post-Infectious Disorders |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |