Treatment Outcomes of Advanced Neoplasia in IBD

Endoscopic and Surgical Treatment Outcomes of Colitis-associated Advanced Neoplasia: a Multicenter Cohort Study

In this study, we aimed to (1) compare cumulative incidences of synchronous and metachronous colorectal neoplasia as well as mortality following AN in CD and UC patients who underwent proctocolectomy, (sub)total colectomy, partial colectomy or endoscopic resection, and (2) to determine factors associated with AN treatment choice.

In this retrospective multicenter cohort study, using PALGA (the Dutch nationwide pathology databank), partial colectomy yielded a similar metachronous neoplasia risk compared to (sub)total colectomy after treatment of advanced neoplasia in inflammatory bowel disease. High metachronous neoplasia rates after endoscopic resection underline the importance of strict subsequent endoscopic surveillance.

Inclusion Criteria:

• IBD (ulcerative colitis (UC), CD or IBD-unclassified (IBD-U))
• Histological diagnosis of colorectal AN
• Available treatment data

Exclusion Criteria:

• Familial CRC syndrome
• AN prior to IBD diagnosis