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| Name | Class |
|---|---|
| Rijnstate Hospital | OTHER |
| Jeroen Bosch Ziekenhuis | OTHER |
| University Medical Center Groningen | OTHER |
| Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
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In this study, we aimed to (1) compare cumulative incidences of synchronous and metachronous colorectal neoplasia as well as mortality following AN in CD and UC patients who underwent proctocolectomy, (sub)total colectomy, partial colectomy or endoscopic resection, and (2) to determine factors associated with AN treatment choice.
In this retrospective multicenter cohort study, using PALGA (the Dutch nationwide pathology databank), partial colectomy yielded a similar metachronous neoplasia risk compared to (sub)total colectomy after treatment of advanced neoplasia in inflammatory bowel disease. High metachronous neoplasia rates after endoscopic resection underline the importance of strict subsequent endoscopic surveillance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IBD patients with advanced neoplasia | IBD patients with advanced neoplasia (high-grade dysplasia or colorectal cancer) treated with:
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endoscopic or surgical resection | Procedure | endoscopic or surgical (partial, (sub)total, proctocolectomy) resection |
|
| Measure | Description | Time Frame |
|---|---|---|
| Synchronous | defined as co-existence of two or more neoplastic colorectal lesions detected in the initial resection specimen or up to 6 months after treatment of the index lesion, categorized in (a) any neoplasia (independent of grade) and (b) only AN | up to 6 months |
| Metachronous (advanced) neoplasia | defined as colorectal neoplasia detected >6 months after treatment of index AN, categorized in (a) any neoplasia (independent of grade) and (b) only AN, including the impact of IBD type | up to 30 years |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause mortality | All-cause mortality | up to 30 years |
| Associations with treatment choice | Clinical and disease characteristics associated with AN treatment choice |
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Inclusion Criteria:
Exclusion Criteria:
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IBD patients with advanced neoplasia
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| Name | Affiliation | Role |
|---|---|---|
| Frank Hoentjen, MD, PhD | Radboudumc and University of Alberta | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Radboudumc | Nijmegen | Gelderland | 6525GA | Netherlands |
Data available upon reasonable request.
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| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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| ID | Term |
|---|---|
| D004724 | Endoscopy |
| ID | Term |
|---|---|
| D003949 | Diagnostic Techniques, Surgical |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D019060 | Minimally Invasive Surgical Procedures |
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| OTHER |
| Amsterdam UMC, location VUmc | OTHER |
| Erasmus Medical Center | OTHER |
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| up to 30 years |
| D013514 | Surgical Procedures, Operative |