Vasopressor Support, Mean Arterial Pressure and Capillary Refill Time in Critically Ill Patients

Influence of Vasopressor Support and Mean Arterial Pressure on Capillary Refill Time Values in Critically Ill Patients: Prospective, Observational Study

The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in crtically ill patients. The main questions it aims to answer are:

• How do vasopressor drugs determine CRT value
• How does mean arterial pressure (MAP) determine CRT value
• How often CRT value is normal (< 3 sec) despite hypotensive MAP (<65 mmHg)

Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value.

The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in critically ill patients. The main questions it aims to answer are:

• How does norepinephrine dose influence CRT value
• How does epinephrine dose influence CRT value
• How does argipressin dose influence CRT value
• How does dobutamine dose influence CRT value
• How does mean arterial pressure (MAP) determine CRT value
• How often CRT value is normal (< 3 sec) despite hypotensive MAP (<65 mmHg)

Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value. CRT will be a dependent variable. Independent variables will be as follows: age, MAP, norepinephrine dose, epinephrine dose, argipressin dose, dobutamine dose.

CRT measurements will be performed in a standarized rigor (light, chronometer, pressure and ambient temperature will be the same in all patients)

Inclusion Criteria:

• critical illness requiring vasopressor support
• invasive blood pressure monitoring

Exclusion Criteria:

• finger distal phalanx not available
• patient in a room of suboptimal ambient temperature