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This was a randomized, double-blind, placebo-controlled parallel study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Jaktinib | Experimental | Jaktinib 100mg BID |
|
| Placebo | Placebo Comparator | placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Jaktinib | Drug | 100mg of Jaktinib (given as two 50mg tablets) administered orally Twice daily(BID) with best available treatment. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to Recovery | Recovery assessed by the National Institute of Allergy and Infectious Diseases Ordinal Scale (NIAID-OS). Time to reach NIAID-OS 1, 2, or 3 for the first time. NIAID-OS: 1 Not hospitalized, no limitations on activities. 2 Not hospitalized, limitation on activities and/or requiring home oxygen. 3 Hospitalized, not requiring supplemental oxygen - no longer requires ongoing medical care. | Day 1 to Day 28 |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of participants who require invasive mechanical ventilation due to disease progression at Day 3, 7, 1 4 or EOT | Day 3, 7, 14 or EOT | |
| Mortality | Proportion of patients with all-cause mortality at Day 28 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jianya Zhou | Contact | 0571-87235114 | zhoujianya@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Jianya Zhou | First Affiliated Hospital of Zhejiang University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of College of Medicine Zhejiang University | Hangzhou | Zhejiang | 310000 | China |
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| ID | Term |
|---|---|
| D011014 | Pneumonia |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| Placebo | Drug | Placebo (given as two placebo tablets) administered orally BID with best available treatment. |
|
| Day 1 to Day 28 |
| D011024 |
| Pneumonia, Viral |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |