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| Name | Class |
|---|---|
| Saint Vincent's Hospital, Korea | OTHER |
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Primary research purpose:
-Prospective study to screen post stroke patients with sarcopenia and evaluate its effect on recovery
Secondary research purpose:
Patients with first-ever stroke will be enrolled and assessed for sarcopenia. The evaluation parameters will include standard sarcopenia parameters and also SEMG-based signals and imaging studies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stroke patients with sarcopenia | Group will be stratified according to gender |
| |
| Stroke patients without sarcopenia | Group will be stratified according to gender |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DEXA Scan | Diagnostic Test | Fu of diagnostic tests |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of Modified Rankin Scale | Functional Disability -> The scale runs from 0-6, running from perfect health without symptoms(0) to death(6). | 6 months from the first onset of the stroke |
| Measure | Description | Time Frame |
|---|---|---|
| Hand grip strength | Grip strength: Grip strength will be measured using a dynamometer | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke |
| quadriceps muscle strength |
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Inclusion Criteria:
Exclusion Criteria:
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Recruited subjects will be allocated into 4 different groups according to presence of sarcopenia according to the Asian Working Group for Sarcopenia (2019) criteria.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Catholic University of Korea | Bucheon-si, Gyeonggi-do | 14647 | South Korea | |||
| St. Vincent's Hospital |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D015502 | Absorptiometry, Photon |
| ID | Term |
|---|---|
| D011859 | Radiography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Lower extremity strength assessment:change in isometric quadriceps muscle strength (kg) from initial evaluation to the final evaluation
| within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke |
| Fugl-Meyer motor scale | Motor function assessment : Fugl-Meyer motor scale from initial evaluation to the final evaluation (Upper Extremity maximum score = 66; Lower Extremity maximum score = 34, Higher score means better outcome) | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke |
| Functional Ambulation Category | Gait function assessment : Functional Ambulation Category from initial evaluation to the final evaluation (Minimum 0, Maximum 5; Higher score means better outcome) | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke |
| Berg balance scale | Balance function: change in Berg balance scale from initial evaluation to the final evaluation (Minimum score 0, Maximum score 56, Higher score means better outcome) | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke |
| Brain MRI | Brain atrophy : change in the Global cortical atrophy scale(0-3) of the cerebral cortex from initial evaluation to the final evaluation | within 4 weeks and 6 months from the first onset of the stroke |
| Thigh Dixon MRI | Muscle quality : muscle circumference measured by the thigh MRI from initial evaluation to the final evaluation | within 4 weeks and 6 months from the first onset of the stroke |
| Muscle ultrasonography | muscle thickness(cm) measured by the ultrasound of the quadriceps muscle from initial evaluation to the final evaluation | within 4 weeks and 6 months from the first onset of the stroke |
| serum biomarkers for sarcopenia | BNDF, IL-6 | within 4 weeks from the first onset of the stroke |
| Digitalized SEMG signals | state of the art EMG signals will be collected to assess muscle quality changes after stroke | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke |
| Suwon |
| 16247 |
| South Korea |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D003720 |
| Densitometry |
| D010783 | Photometry |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |