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| Name | Class |
|---|---|
| University of Bern | OTHER |
| Wageningen University | OTHER |
| Queen's University, Belfast | OTHER |
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The goal of this observational study is to learn about changes in oral processing and appetite in older adults aged 65+ years old. The main question it aims to answer is if oral processing affects gastric emptying in older adults (≥65 years old).
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| Measure | Description | Time Frame |
|---|---|---|
| Objective appetite assessment: Ad-libitum meal consumption | Consumption of the ad-libitum meal is measured (g). Participants are instructed to eat until they feel comfortable full | During the procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective appetite assessment: VAS | Appetite are assessed using a 100 mm Visual Analogue Scales (VAS, scale 0-100) | During the procedure |
| Gastric Emptying | Gastric emptying is measured using of 100 microliters of 13C Octanoic Acid breath test |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy adults aged 65 years old or older
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| Name | Affiliation | Role |
|---|---|---|
| Miriam Clegg, BSc, PhD | m.e.clegg@reading.ac.uk | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Reading | Reading | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25179444 | Background | Tada A, Miura H. Systematic review of the association of mastication with food and nutrient intake in the independent elderly. Arch Gerontol Geriatr. 2014 Nov-Dec;59(3):497-505. doi: 10.1016/j.archger.2014.08.005. Epub 2014 Aug 17. | |
| 32965067 | Background | Pina GMS, Mota Carvalho R, Silva BSF, Almeida FT. Prevalence of hyposalivation in older people: A systematic review and meta-analysis. Gerodontology. 2020 Dec;37(4):317-331. doi: 10.1111/ger.12497. Epub 2020 Sep 23. |
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No personal identification data will be shared. The study is not under an obligation to share data, however, it is possible that some of the individual (unlinked / non-identifiable) data will be useful in a meta-analysis and, hence sharing individual participant data (IPD) will be considered.
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| During the procedure |
| Chewing rate | Chewing rate would be assessed with recording the preload breakfast meal provided and analysing the video recording in software (ELAN 6.4) for number of chews, bites, swallows, time of food in the mouth. | During the procedure |
| Salivary flow rate | Stimulated and unstimulated salivary flow rate would be assessed with passive drooling method. | During the procedure |
| BMI | BMI is assessed by using a body composition monitor (OMRON Viva) | During the procedure |
| Oral Health | Oral Health will be assessed by using an Oral Health Questionnaire | During the procedure |
| Chewing ability | Chewing ability will be assessed by using a colour mixing ability chewing gum test (Heu-Check test, University of Bern) | During the procedure |
| Glucose | Glucose will be assessed from finger prick blood samples | During the procedure. Every 15 minutes for the first hour after the meal and every 30 minutes thereafter till the end of the total 3 hours |
| Insulin | Insulin will be assessed from finger prick blood samples | During the procedure. Every 15 minutes for the first hour after the meal and every 30 minutes thereafter till the end of the total 3 hours |
| Salivary a-amylase | Salivary a-amylase activity will be assessed from the stimulated saliva collected, by using a-amylase kinetic kit | During the procedure |
| 2898107 | Background | Morley JE, Silver AJ. Anorexia in the elderly. Neurobiol Aging. 1988 Jan-Feb;9(1):9-16. doi: 10.1016/s0197-4580(88)80004-6. |
| 29408331 | Background | Krop EM, Hetherington MM, Nekitsing C, Miquel S, Postelnicu L, Sarkar A. Influence of oral processing on appetite and food intake - A systematic review and meta-analysis. Appetite. 2018 Jun 1;125:253-269. doi: 10.1016/j.appet.2018.01.018. Epub 2018 Feb 22. |