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| Name | Class |
|---|---|
| Peking University Third Hospital | OTHER |
| Chinese Academy of Medical Sciences, Fuwai Hospital | OTHER |
| Beijing Anzhen Hospital | OTHER |
| Guangdong Provincial People's Hospital |
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The goal of this clinical trial is to monitor hemodynamic differences between central veno-arterial extracorporeal membrane oxygenation (VA ECMO) and peripheral VA ECMO. The main question it aims to answer is:
Participants require VA ECMO support, will be divided into two groups in an intention-to-treat analysis: central artery cannulation and peripheral artery cannulation.
Researchers will analyze different cannulation strategies for VA-ECMO and identify potential advantages and disadvantages for two groups of VA-ECMO.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Peripheral VA ECMO | Femoral artery cannulation for veno-arterial extracorporeal membraneous oxygenation (VA ECMO) |
| |
| Central VA ECMO | Axillary artery cannulation for veno-arterial extracorporeal membraneous oxygenation (VA ECMO) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Veno-arterial extracorporeal membrane oxygenation | Procedure | Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is mainly used for circulatory support in patients with severe cardiopulmonary failure. VA ECMO drains the blood from the venous system followed pumping the blood back into the arterial vascular compartment after oxygenation. It can be divided into two cannulation strategies for VA ECMO support, namely peripheral VA ECMO and central VA ECMO based on the arterial cannulation site. Peripheral VA ECMO is established via the femoral artery (FA), whereas axillary artery (AX) is an arterial cannulation site in central VA-ECMO. |
| Measure | Description | Time Frame |
|---|---|---|
| Oxygen saturation-no. (%) | Blood gas analysis | Through VA ECMO support completion, an average of 1 week |
| Left ventricular end-diastolic volume (ml) | echocardiography | Through VA ECMO support completion, an average of 1 week |
| Left ventricular End-systolic volume (ml) | echocardiography | Through VA ECMO support completion, an average of 1 week |
| Stroke volume (ml) | echocardiography | Through VA ECMO support completion, an average of 1 week |
| Mitral valve area(cm2) | echocardiography | Through VA ECMO support completion, an average of 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of successful weaning from VA ECMO | Weaning success is defined as survival after complete removal of the extracorporeal circuit without requirement for further mechanical support or heart transplant. | Through study completion, up to 2 years |
| VA ECMO duration |
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Inclusion Criteria:
Exclusion Criteria:
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Participants require VA ECMO support for cardiogenic shock or cardiac arrest.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yang Yan | Contact | 0086-18991232621 | yangyan3@xjtu.edu.cn | |
| Fengwei Guo | Contact | 0086-13991259800 | guofengwei@xjtu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Yang Yan | First Affiliated Hospital of Xian Jiaotong University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Xi'an Jiaotong University | Recruiting | Xi'an | Shaanxi | 710061 | China |
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| ID | Term |
|---|---|
| D012770 | Shock, Cardiogenic |
| D006323 | Heart Arrest |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D015199 | Extracorporeal Membrane Oxygenation |
| ID | Term |
|---|---|
| D012138 | Respiratory Therapy |
| D013812 | Therapeutics |
| D005112 | Extracorporeal Circulation |
| D013514 | Surgical Procedures, Operative |
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| OTHER |
| Shaanxi Provincial Center for Disease Control and Prevention | OTHER |
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Length of VA ECMO support |
| Through VA ECMO support, an average of 1 week |
| Cannulation-related complications | Cannulation-related complications include bleeding, limb ischemia, revision of cannulation site, wound complications. Limb ischemia is defined as ischemia requiring any surgical procedure, including revision of the arterial/distal perfusion cannula, fasciotomy for compartment syndrome, gangrene, or amputation. Wound complication is defined as infection or requirement of an additional surgical intervention, such as arterial repair, washout with or without vacuum-assisted closure, and muscle flap closure. | Through study completion, up to 2 years |
| Duration of ICU stay | Intensive care unit length of stay | Through study completion, up to 2 years |
| Duration of hospital stay | Length of hospital stay | Through study completion, up to 2 years |
| D014652 |
| Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D012769 | Shock |