Endocan Biomarker Level in Gingival Crevicular Fluid in Periodontitis Patients With Type 2 Diabetes Mellitus

Endocan Biomarker Level in Gingival Crevicular Fluid in Periodontitis Patients With Type 2 Diabetes Mellitus [A Comparative Cross-Sectional Study]

Aim of the current study was to evaluate Endocan biomarker level in gingival crevicular fluid of patients with stage 1 or 2 (mild to moderate) periodontitis with controlled type 2 diabetes mellitus (DM) and compare it to that in DM free periodontitis patients.

Inclusion Criteria:

• Probing pocket depths (PPD) ≤ 5 mm.
• Clinical attachment level (CAL) ≤ 4 mm.
• Type 2 DM, for at least the past 3 years.
• HbA1c ≤ 7%.

Exclusion Criteria:

• Uncontrolled Diabetes Mellitus.
• Systemic antibiotic or anti-inflammatory medication use in the previous 2 months.
• Non-surgical periodontal therapy in the previous 6 months.
• Surgical periodontal therapy in the previous 12 months.
• Use of calcium channel blockers, phenytoin, or cyclosporine.
• Pregnancy.
• Smokers