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This observational and retrospective study will follow the recommendations of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). The aim is to verify and analyze the clinical and laboratory variables with prediction capability for indication of invasive ventilatory support in patients with COVID-19. The present study will be carried out in specific care units for patients with suspected or confirmed COVID-19. Individuals with suspected or clinical diagnosis of COVID-19, with a minimum hospital stay of 24 hours and submitted to oxygen therapy or non-invasive ventilation will be selected. Clinical and laboratory variables will be collected from the moment of admission and every 12 hours until the third day of hospitalization. The primary outcome will be rate of endotracheal intubation, while secondary outocomes will be lenght of stay in intensive care unit, and hospital, as well as mortality rate.
Clinical and laboratory data will be collected from medical records from the period of the COVID-19 pandemic (February 2020 to June 2021)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| orotracheal intubation group | Composed of Patients who were intubated after 48 hours of admission to the intensive care unit |
| |
| non-intubated group | Composed of patients who were not intubated during their stay in the intensive care unit |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| orotracheal intubation | Procedure | Clinical and laboratory data will be collected from patients who are intubated after 48 hours of admission to the intensive care unit |
|
| Measure | Description | Time Frame |
|---|---|---|
| Identify clinical and laboratory variables that may be associated with the need of endotracheal intubation in the first 72 hours of admission to the intensive care unit. | Vital signs will be collected through the cardiac monitor and clinical evaluation from the moment of admission until the third day of hospitalization, every twelve hours and full blood count and biochemistry data will be collected from patients at admission until the third day of hospitalization in the intensive care unit | 3 days |
| Measure | Description | Time Frame |
|---|---|---|
| time to endotracheal intubation | It will be collected from the date of intensive care unit admission until the date of endotracheal intubation | 28 days |
| length of stay in the ICU | It will be collected from the date of intensive care unit admission until the outcome of discharge from the intensive care unit or death. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with confirmation of covid-19 and with length of stay in the intensive care unit greater than 48 hours will be selected for the intubated and non-intubated groups. For the intubated group, patients who underwent endotracheal intubation after 48 hours of admission to the intensive care unit will be selected. For the non-intubated group, those patients who were not intubated during their stay in the intensive care unit will be selected.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pedro Ernesto University Hospital | Rio de Janeiro | 20551-030 | Brazil | |||
| National Institute of Infectology Evandro Chagas |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39167241 | Derived | Maia G, Martins CM, Marques V, Christovam S, Prado I, Moraes B, Rezoagli E, Foti G, Zambelli V, Cereda M, Berra L, Rocco PRM, Cruz MR, Samary CDS, Guimaraes FS, Silva PL. Derivation and external validation of predictive models for invasive mechanical ventilation in intensive care unit patients with COVID-19. Ann Intensive Care. 2024 Aug 21;14(1):129. doi: 10.1186/s13613-024-01357-4. |
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|
| 6 months |
| length of hospital | It will be collected from the date of intensive care unit admission until the outcome of hospital discharge or death. | 12 months |
| mechanical ventilation days | It will be collected from the date of intubation in the intensive care unit until the date of extubation or up to 48 hours off mechanical ventilation in cases of tracheostomized patients and/or until the outcome of death | 6 months |
| hospital mortality | Mortality will be collected during the period of hospitalization | 12 months |
| Rio de Janeiro |
| 21040-360 |
| Brazil |
| Clementino Fraga Filho University Hospital | Rio de Janeiro | 21941-617 | Brazil |
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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