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The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood.
The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood. After an initial period (2-4 weeks) of mood and lifestyle monitoring using smartphone and smartwatch data, participants will be assigned to an evidenced-based behavioral plan that target their lifestyle for 6 weeks. The trial will evaluate changes in depressed mood, associated health behaviors and cognition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Personalized Behavioral Intervention | Experimental | Behavioral lifestyle intervention assigned according to each participant's mood and lifestyle data patterns. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Personalized Behavioral Intervention | Behavioral | Behavioral lifestyle intervention assigned according to each participant's mood and lifestyle data patterns. |
|
| Measure | Description | Time Frame |
|---|---|---|
| PHQ9 | Depression Symptoms on the Patient Health Questionnaire 9-item (PHQ9) scale, min 0 max 27 with lower scores representing better outcome | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jyoti Mishra, PhD | University of California, San Diego | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UC San Diego Health Psychiatry | San Diego | California | 92127 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42151558 | Derived | Nan J, Purpura S, Jaiswal S, Afshar H, Maric V, Manchanda JK, Taylor CT, Ramanathan D, Mishra J. Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study. NPP Digit Psychiatry Neurosci. 2026 May 19;4(1):10. doi: 10.1038/s44277-026-00062-3. |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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